| Project/Area Number |
26460262
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
Duncan W. Colin 英国エジンバラ大学, The Queen's Medical Retsearch Institute, Centre for Reproductive Health, 教授
Kudo Masataka 北海道大学, 大学院医学研究科, 准教授 (70281821)
Okuda Kiyoshi 帯広畜産大学, 学長 (40177168)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 糖脂質 / 黄体 / ガレクチン / シアル酸 / プロゲステロン / プロスタグランジン / hCG / LHCGR / 脂質ラフト / ガングリオシド / プロジェステロン / ｈCG |
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| Outline of Final Research Achievements |
The corpus luteum (CL) is formed in the ovary from an ovulated follicle, and secretes progesterone essential for the establishment and maintenance of pregnancy. In non-fertile cycle, the CL undergoes a regressing stage called luteolysis, while its function is maintained by human chorionic gonadotropin from the implanted embryo during fertile cycle in women. In most animals including mice and ruminants, prostaglandin F secreted from the uterus is an initiator for luteolysis; however, the mechanism how luteolysis in women is regulated is still unknown. We here demonstrated that the changes in the quality and quantity of glycosphingolipids play an important role in the regulation of spontaneous luteolysis in women as well as mice and cows.
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