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Molecular mechanisms in the hormone-dependent differentiation of the mouse submandibular gland

Research Project

Project/Area Number 26460270
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionKanazawa University

Principal Investigator

ISEKI Shoichi  金沢大学, 医学系, 教授 (50167251)

Co-Investigator(Renkei-kenkyūsha) WAKAYAMA TOMOHIKO  熊本大学, 大学院生命科学研究部, 教授 (70305100)
YAMAMOTO MIYUKI  金沢大学, 医学系, 助教 (60139780)
NAKATA HIROKI  金沢大学, 医学系, 講師 (80638304)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords細胞分化 / 組織形成 / 顎下腺 / 導管系 / アンドロゲン / 甲状腺ホルモン / 受容体 / カルパイン / セルピン / カリクレイン / マウス / 性差 / 顆粒性導管 / マウス顎下腺 / 生後発達 / ケラチン5 / カルパイン3
Outline of Final Research Achievements

Of the two kinds of sexual dimorphism in the mouse submandibular gland (SMG), the preferential increase of granular convoluted tubule (GCT) cells in males was lacking in androgen receptor (AR)-deficient mice (ARKO) and, thus, proved to be dependent on AR, whereas the administration of thyroid hormone (T4) to ARKO caused increase of GCT cells independent of AR. On the other hand, the preferential decrease of granular intercalated duct (GID) cells in males was lacking in ARKO, and administration of T4 caused no decrease of GID cells, suggesting that the two kinds of sexual dimorphism have different hormone dependency. Furthermore, the gene expression profile of the normal and ARKO SMG identified numbers of new GCT-specific gene products.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report

Research Products

(13 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 5 results,  Open Access: 1 results) Presentation (8 results)

  • [Journal Article] Synthesis,localization,and possible function of the serine (or cysteine) peptidase inhibitor,clade B,member6a (Serpinb6a)in the submandibular gland of mice2017

    • Author(s)
      Nakata H, Yamamoto M, Kumchantuek T, Adhapanyawanich K, Nishiuchi T, Iseki S
    • Journal Title

      Cell and Tissue Research

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Expression and localization of calpain 3 in the submandibular gland of mice2016

    • Author(s)
      Kumchantuek T, Nakata H, Sakulsak N, Yamamoto M, Iseki S
    • Journal Title

      Archives of Oral Biology

      Volume: 70 Pages: 9-15

    • DOI

      10.1016/j.archoralbio.2016.05.019

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Immunohistochemical localization of keratin 5 in the submandibular gland in adult and postnatal developing mice2016

    • Author(s)
      Miyuki Yamamoto, Hiroki Nakata,Tewarat Kumchantuek, Natthiya Sakulsak, Shoichi Iseki
    • Journal Title

      Histochemistry and Cell Biology

      Volume: 145(3) Pages: 327-339

    • DOI

      10.1007/s00418-015-1392-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Morphology and gene expression profile of the submandibular gland of androgen-receptor-deficient mice2015

    • Author(s)
      Kannika Adthapanyawanich, Tewarat Kumchantuek, Hiroki Nakata, Miyuki Yamamoto, Tomohiko Wakayama, Takumi Nishiuchi, Shoichi Iseki
    • Journal Title

      Archives of Oral Biology

      Volume: 60 (2) Pages: 320-332

    • DOI

      10.1016/j.archoralbio.2014.11.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expression and Localization of α-amylase in the Submandibular and Sublingual Glands of Mice2014

    • Author(s)
      Rhoko Yamagishi, Tomohiko Wakayama, Hiroki Nakata, Kannika Adthapanyawanich, Tewarat Kumchantuek, Miyuki Yamamoto, Shoichi Iseki
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 47 (3) Issue: 3 Pages: 95-102

    • DOI

      10.1267/ahc.14005

    • NAID

      130004137835

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 野生型およびアンドロゲン受容体KOマウスにおける顆粒性介在部細胞の生後発達とホルモンによる影響2017

    • Author(s)
      山本美由紀,井関尚一
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学医学部(長崎県)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞の増殖・分化モデルとしてのマウス・ラット顎下腺2016

    • Author(s)
      井関尚一
    • Organizer
      第53回日本口腔組織培養学会学術大会・総会
    • Place of Presentation
      石川県立美術館(石川県)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 野生型およびアンドロゲン受容体KOマウスにおける顆粒性介在部細胞の生後発達とホルモンによる影響2016

    • Author(s)
      山本美由紀,Tewarat Kumchantuek, 井関尚一
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Expression and localization of calpain 3 in the submandibular gland of mice2016

    • Author(s)
      Tewarat Kumchantuek, Hiroki Nakata, Miyuki Yamamoto, Shoichi Iseki
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス顎下腺におけるカルパイン3の発現と局在2015

    • Author(s)
      Tewarat Kumchantuek,仲田浩規,山本美由紀,井関尚一
    • Organizer
      日本解剖学会第75回中部支部学術集会
    • Place of Presentation
      福井大学医学部キャンパス(福井県)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Morphological and histochemical features of the intercalated duct in the submandibular gland of mice deficient for androgen receptor2015

    • Author(s)
      Miyuki Yamamoto, Tewarat Kumchantuek, Shoichi Iseki
    • Organizer
      第120回日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Morphology and gene expressio profile of the submandibular gland of androgen receptor-deficient mice2015

    • Author(s)
      Tewarat Kumchantuek, Kannika Adthapanyawanich, Hiroki Nakata, Miyuki Yamamoto, Tomohiko Wakayama, Takumi Nishiuchi, Shoichi Iseki
    • Organizer
      第120回日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] アンドロゲン受容体欠損マウスにおける顎下腺導管系の分化2014

    • Author(s)
      Tewarat Kumchantuek、仲田浩規、山本美由紀、若山友彦、井関尚一
    • Organizer
      日本解剖学会第74回中部支部学術集会
    • Place of Presentation
      金沢大学宝町キャンパス(石川県)
    • Year and Date
      2014-10-11 – 2014-10-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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