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influence of trisomy 21 on early neural differentiation

Research Project

Project/Area Number 26460275
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionTottori University

Principal Investigator

Hiratsuka Masaharu  鳥取大学, 医学部, 助教 (00362872)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords遺伝子発現モニター / 人工染色体 / 神経分化誘導
Outline of Final Research Achievements

Chromosomal abnormalities, such as Trisomy for human chromosome 21 (Down syndrome), are thought to be the most common cause of mental retardation. To gain insight into the underlying cellular pathogenesis, we made a new system to monitor differentiation process from forebrain neural precursor cells into interneurons and oligodendrocytes by using a human artificial chromosome vector.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2015 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Remarks (1 results)

  • [Journal Article] Development of a Safeguard System using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy.2015

    • Author(s)
      Uno N, Uno K, Komoto S, Suzuki T, Hiratsuka M, Osaki M, Kazuki Y, Oshimura M.
    • Journal Title

      Mol Ther Nucleic Acids.

      Volume: 4 Pages: e272-e272

    • DOI

      10.1038/mtna.2015.45

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome2015

    • Author(s)
      Hiratsuka M, Ueda K, Uno N, Uno K, Fukuhara S, Kurosaki H, Takehara S, Osaki M, Kazuki Y, Kurosawa Y, Nakamura T, Katoh M, Oshimura M
    • Journal Title

      BMC Biotechnol.

      Volume: 15 Issue: 1 Pages: 58-58

    • DOI

      10.1186/s12896-015-0142-z

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Remarks] 鳥取大学 医学部 生命科学科 細胞工学

    • URL

      http://saiboukougaku.jimdo.com/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2021-01-27  

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