The translation inhibitor Pdcd4 is involved in the induction of cell differentiation
| Project/Area Number |
26460276
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kumamoto University |
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Principal Investigator |
Eto Ko 熊本大学, 大学院先端科学研究部(理), 准教授 (40359964)
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| Research Collaborator |
Ushio Ayako
Yamada Satomi
Anai Chikara
Muraoka Akihiko
Hashimoto Airi
Takaki Syohei
Ikeda Saki
Kashima Rui
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Cell differentiation / mRNA translation / Translation inhibitor / Neurogenesis / Myogenesis / Pdcd4 / 細胞分化 / mRNAの翻訳阻害 / 翻訳抑制因子Pdcd4 / RNA結合タンパク質RBM3 / 遺伝子発現の転写後制御 / 分化抑制因子 / 増殖促進因子 / mRNAの翻訳抑制 |
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| Outline of Final Research Achievements |
Undifferentiated cells can not only self-replicate but also differentiate. During cell differentiation, the expression of genes specific for undifferentiated cells is suppressed and then that of genes specific for differentiated cells is promoted. The present study indicated that increased levels of Pdcd4, a translation inhibitor suppressing mRNA translation, caused decreased levels of genes expressing in undifferentiated cells, inducing cell differentiation. Thus, Pdcd4 may be a molecular switch for undifferentiated cells to convert from their self-replication state to their differentiation state.
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Report
(4 results)
Research Products
(34 results)
