| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The multi-morphological cell death was founded in at least two organs of continuous stress (CS) loaded rat. One of them was appeared in the pituitary intermediate cells, melanotrophs, which was activated hormone production and secretion under CS. The other was detected in the liver. Some hepatocyte located perivenous area expressed necrotic morphology. In the CS rat, perivenous hepatocytes continuously increased lipid metabolism and this might induce oxidative stress. On the other hand, anti-oxidant reactions and intracellular recycling systems were activated as protective effects, but a part of hepatocyte seemed to be unavoidable from the stress. The dyeing processes both in hepatocytes and melanotrophs under CS were common characteristic. Such as cell death possibly become a risk factor for the organ homeostasis in the case of stress prolongation more long time.
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