| Project/Area Number |
26460283
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IMAMURA Kazuyuki 前橋工科大学, 工学部, 教授 (30203326)
SAKAKIBARA Shin-ichi 早稲田大学, 人間科学学術院, 教授 (70337369)
UEDA Shuichi 獨協医科大学, 医学部, 教授 (60150570)
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| Research Collaborator |
SHIGEMOTO Ryuichi Institute of Science and Technology, 教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | コネクトミクス解析 / 視覚野 / シナプス / 眼優位可塑性 / 電子顕微鏡 / 三次元再構築 / コネクトミクス / 視覚野可塑性 / シナプス回路 |
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| Outline of Final Research Achievements |
To clarify the mechanism of the neural circuit reorganization, we have established connectomics analysis of visual cortex. After monocular deprivation, the neurons in the visual cortex were more received from open eye input. As a result of having immunohistochemically analyzed using c-Fos, FosB and CREB, these activity dependence inducted proteins were resulted to detect the changes of ocular dominance plasticity. Using connectomics analysis, synaptic connections were cyclopedically analyzed in layer IV of visual cortex. As a result, we detected that first the synapses received from deprived eye input were reduced, next the synapses received from opened eye input were increased.
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