| Project/Area Number |
26460284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鯉沼 聡 近畿大学, 医学部, 講師 (10340770)
升本 宏平 近畿大学, 医学部, 助教 (60580529)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 視交叉上核 / ゲート機構 / 網膜 / 概日リズム / 網膜神経節細胞 / 体内時計 / ゲート |
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| Outline of Final Research Achievements |
We investigated the mechanisms of gating system of responses to light in the suprachiasmatic nucleus (SCN), mammalian circadian center. We got several new findings. (1) In the rat, the circadian oscillator in the dorsomedial SCN (DMSCN) determines the phase of the gate, which regulate responses to photic signal in the ventrolateral SCN(VLSCN). Then the gating system also locates in the retinal ganglion cell layer. (2) In the mouse, the circadian oscillator in the shell region within SCN also determines the phase of the gate in the SCN. In addition, the retinal gating system resides in the intrinsically photosensitive retinal ganglion cells (ipRGCs).
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