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Roles of LPS, cytokine and peripheral CRF receptors on gastrointestinal function

Research Project

Project/Area Number 26460287
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General physiology
Research InstitutionAsahikawa Medical College

Principal Investigator

Nozu Tsukasa  旭川医科大学, 医学部, 准教授 (30312367)

Co-Investigator(Kenkyū-buntansha) 奥村 利勝  旭川医科大学, 医学部, 教授 (60281903)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords内臓知覚 / 消化管運動 / ストレス / CRF / 過敏性腸症候群 / 内臓感覚 / サイトカイン / LPS / dopamine / IL-1 / CRF受容体 / 大腸運動 / 胃運動
Outline of Final Research Achievements

Corticotropin-releasing factor (CRF) exerts the action via CRF receptor subtype 1 (CRF1) and subtype 2 (CRF2). We demonstrated that enhanced colonic contractility and visceral hypersensitivity induced by stress were CRF1-triggered responses, and CRF2 suppressed these ones. Moreover, the signal balance of CRF1 and CRF2 may determined these colonic functional changes. Therefore, we advocated the balance theory of CRF signaling. Incidentally, we also showed that visceral hypersensitivity induced by stress was mediated via LPS-cytokine system, and CRF also regulated the immune system to contribute to this altered visceral sensation. Moreover, this response followed the balance theory of CRF signaling.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015 2014

All Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Acknowledgement Compliant: 6 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Lovastatin inhibits visceral allodynia and increased colonic permeability induced by lipopolysaccharide or repeated water avoidance stress in rats.2018

    • Author(s)
      Nozu T, Miyagishi S, Kumei S, Nozu R, Takakusaki K, Okumura T
    • Journal Title

      Eur J Pharmacol.

      Volume: 818 Pages: 228-234

    • DOI

      10.1016/j.ejphar.2017.10.056

    • NAID

      120006552898

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A glucagon-like peptide-1 analog, liraglutide improves visceral sensation and gut permeability in rats2017

    • Author(s)
      Nozu T, Miyagishi S, Kumei S, Nozu R, Takakusaki K, Okumura T.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: in press Issue: 1 Pages: 232-239

    • DOI

      10.1111/jgh.13808

    • NAID

      120006462336

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lipopolysaccharide induces visceral hypersensitivity: role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor in rats.2017

    • Author(s)
      Nozu T, Miyaghisi S, Nozu R, Takakusaki K, Okumura T.
    • Journal Title

      J Gastroenterol.

      Volume: 80(5) Issue: 1 Pages: 70-82

    • DOI

      10.1007/s00535-016-1208-y

    • NAID

      120006220854

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor2017

    • Author(s)
      Nozu T, Miyagishi S, Nozu R, Takakusaki K, Okumura T.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: in press Issue: 12 Pages: 1958-1965

    • DOI

      10.1111/jgh.13787

    • NAID

      120006425800

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Water avoidance stress induces visceral hyposensitivity through peripheral corticotropin releasing factor receptor type 2 and central dopamine D2 receptor in rats2016

    • Author(s)
      Nozu, T. Miyagishi, S. Nozu, R. Takakusaki, K. Okumura, T.
    • Journal Title

      Neurogastroenterol Motil

      Volume: 28 Issue: 4 Pages: 522-531

    • DOI

      10.1111/nmo.12747

    • NAID

      120005941041

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Colorectal distention induces acute and delayed visceral hypersensitivity: role of peripheral corticotropin-releasing factor and interleukin-1 in rats2015

    • Author(s)
      Nozu, T. Kumei, S. Miyagishi, S. Takakusaki, K. Okumura, T.
    • Journal Title

      J Gastroenterol

      Volume: 50 Issue: 12 Pages: 1153-1161

    • DOI

      10.1007/s00535-015-1070-3

    • NAID

      120005740467

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Corticotropin-releasing factor receptor type 1 and type 2 interaction in irritable bowel syndrome2015

    • Author(s)
      Nozu, T. Okumura, T.
    • Journal Title

      J Gastroenterol

      Volume: 50 Issue: 8 Pages: 819-830

    • DOI

      10.1007/s00535-015-1086-8

    • NAID

      120005941030

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Urocortin 2 blocks the suppression of gastric antral contractions induced by lipopolysaccharide in freely moving conscious rats2014

    • Author(s)
      Nozu T, Takakusaki K, Okumura T
    • Journal Title

      Regulatory Peptides

      Volume: (in press) Pages: 12-17

    • DOI

      10.1016/j.regpep.2014.04.004

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A balance theory of peripheral corticotropin-releasing factor receptor type 1 and type 2 signaling to induce colonic contractions and visceral hyperalgesia in rats2014

    • Author(s)
      Nozu T, Takakusaki K, Okumura T
    • Journal Title

      Endocrinology

      Volume: 155 Issue: 12 Pages: 4655-4664

    • DOI

      10.1210/en.2014-1421

    • NAID

      120005690949

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Glucagon-like peptide-1アナログ,リラグルチドの内臓知覚と腸管透過性に対する効果について2018

    • Author(s)
      野津 司
    • Organizer
      第 14 回日本消化管学会総会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor2017

    • Author(s)
      T. Nozu, T. Okumura
    • Organizer
      ANMA & JSNM Joint Meeting 2017
    • Place of Presentation
      大阪
    • Year and Date
      2017-03-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Water avoidance stress induces visceral hyposensitivity through peripheral corticotropin releasing factor receptor type 2 and central dopamine D2 receptor in rats2017

    • Author(s)
      T. Nozu, T. Okumura
    • Organizer
      ANMA & JSNM Joint Meeting 2017
    • Place of Presentation
      大阪
    • Year and Date
      2017-03-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ストレス,CRF,過敏性腸症候群2017

    • Author(s)
      野津 司
    • Organizer
      第72回日本大腸肛門病学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 消化管運動と内臓知覚における末梢CRF受容体サブタイプの役割-balance theoryについて2015

    • Author(s)
      野津 司,奥村 利勝
    • Organizer
      日本神経消化器病学会
    • Place of Presentation
      沖縄
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
  • [Presentation] Peripheral corticotropin-releasing factor (CRF) induces stimulation of colonic contractions and visceral hyperalgesia in rats; role of CRF receptor type 1 and 22014

    • Author(s)
      Tsukasa Nozu, Toshikatsu Okumura
    • Organizer
      Japan Digestive Disease Week 2014
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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