| Project/Area Number |
26460287
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
Nozu Tsukasa 旭川医科大学, 医学部, 准教授 (30312367)
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| Co-Investigator(Kenkyū-buntansha) |
奥村 利勝 旭川医科大学, 医学部, 教授 (60281903)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 内臓知覚 / 消化管運動 / ストレス / CRF / 過敏性腸症候群 / 内臓感覚 / サイトカイン / LPS / dopamine / IL-1 / CRF受容体 / 大腸運動 / 胃運動 |
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| Outline of Final Research Achievements |
Corticotropin-releasing factor (CRF) exerts the action via CRF receptor subtype 1 (CRF1) and subtype 2 (CRF2). We demonstrated that enhanced colonic contractility and visceral hypersensitivity induced by stress were CRF1-triggered responses, and CRF2 suppressed these ones. Moreover, the signal balance of CRF1 and CRF2 may determined these colonic functional changes. Therefore, we advocated the balance theory of CRF signaling. Incidentally, we also showed that visceral hypersensitivity induced by stress was mediated via LPS-cytokine system, and CRF also regulated the immune system to contribute to this altered visceral sensation. Moreover, this response followed the balance theory of CRF signaling.
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