| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
In diseased hearts, impaired muscle with reduced contractile strength is distributed throughout the hearts and is stretched by contractions of more viable neighboring muscle during the contraction phase. In addition, it has been reported that muscle stretch transiently increases the production of reactive oxygen species (ROS). The present study demonstrates that, focusing on the ROS production, the passive stretch of the impaired muscle regionally increases the ROS production, accelerate calcium waves arising from the impaired region, and causes triggered arrhythmias.
|
