Effect of regional increase in ROS on arrhythmia susceptibility in the myocardium with nonuniform contraction
Project/Area Number |
26460288
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
|
Research Institution | Tohoku University |
Principal Investigator |
Miura Masahito 東北大学, 医学系研究科, 准教授 (30302110)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 活性酸素 / 細胞内カルシウム / 不整脈 / マウス / 不均一収縮 |
Outline of Final Research Achievements |
In diseased hearts, impaired muscle with reduced contractile strength is distributed throughout the hearts and is stretched by contractions of more viable neighboring muscle during the contraction phase. In addition, it has been reported that muscle stretch transiently increases the production of reactive oxygen species (ROS). The present study demonstrates that, focusing on the ROS production, the passive stretch of the impaired muscle regionally increases the ROS production, accelerate calcium waves arising from the impaired region, and causes triggered arrhythmias.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Effect of Carbenoxolone on Arrhythmogenesis in Rat Ventricular Muscle2016
Author(s)
Masahito Miura, Tsuyoshi Nagano, Naomi Murai, Yuhto Taguchi, Tetsuya Handoh, Minami Satoh, Satoshi Miyata, Lawson Miller, Chiyohiko Shindoh, Bruno D. Stuyvers
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Journal Title
Circulation Journal
Volume: 80
Issue: 1
Pages: 76-84
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Rho-kinase inhibition during early cardiac development causes arrhythmogenic right ventricular cardiomyopathy in mice.2015
Author(s)
Ellawindy A, Satoh K, Sunamura S, Kikuchi N, Suzuki K, Minami T, Ikeda S, Tanaka S, Shimizu T, Enkhjargal B, Miyata S, Taguchi Y, Handoh T, Kobayashi K, Kobayashi K, Nakayama K, Miura M, Shimokawa H.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 35
Issue: 10
Pages: 2172-2184
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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