| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
To elucidate the mechanisms for neuronal migration and intercellular communication steered by ion channels in the embryonic brain, we investigated the mechanisms of ion channel activation induced by the action of guidance molecules that promote migration or repulsion of GABAergic interneuron precursors during development of the cerebral cortex in embryos. We found that potassium ion channels are suppressed and anion channels are activated during migration, and that the regulation of ion channels during both migration and repulsion might be mediated by the rises in intracellular calcium ion concentration.
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