| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Tumor cells predominantly produce energy with high-rate glycolysis followed by lactate formation in their cytoplasm due to their fast proliferation under hypoxic conditions differently from most normal cells producing energy with relatively low-rate glycolysis followed by oxidation of pyruvate in mitochondria. This high-rate glycolysis with lactate formation of tumor cells provides a large amount of H+ leading to acidic microenvironments. Even in environments that tumor cells produce a large amount of H+ due to high-rate glycolysis, the cytosolic pH (pHc) of tumor cells is maintained at a level identical to or even slightly higher than that of normal cells. To maintain pH at a normal level, tumor cells should have higher expression and/or activity of H+ transporting systems than normal cells. The aim of this project is to clarify the differences of pH regulation system in cancer cells and cancer stem cells reading to discovery of new target molecules to treat cancer.
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