| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Vagal afferent nerves are one of visceral sensory nerves linking from the peripheral organ to the brain, and might regulate feeding and metabolisms. Some of postprandial hormones including pancreatic insulin and glucagon, intestinal GLP-1 (glucagon-like peptide-1) and pituitary oxytocin acted on the overlapping population of vagal afferent neurons (approximately 10%). Activation of vagal afferent subclass by the endogenous GLP-1 induced suppression of feeding and improving glucose tolerance. The present study demonstrates that the subclass of vagal afferent activated by postprandial hormones including insulin regulates feeding and glucose metabolism.
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