| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
I investigated the function and physiological role of TASK1 channels in endocrine cells. Pharmacological and molecular biological analyses showed that TASK1 channels are regulated by the clathrin-dependent endocytosis in NGF- and muscarine-stimulated adrenal medullary and PC12 cells. Additionally, it showed that the molecular mechanisms regulating channel endocytosis differ between NGF-induced endocytosis and muscarine-induced endocytosis. The AM cells prepared from TASK1 KO mice indicated the decrease of pH sensitivity and adrenaline secretion, suggesting TASK1 channels play an important role in a sensor of acidosis and adrenaline secretion in AM cells.
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