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The physiological role of TASK channel in adrenaline secretion

Research Project

Project/Area Number 26460306
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General physiology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

Matsuoka Hidetada  産業医科大学, 医学部, 講師 (90374991)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsTASKチャネル / エンドサイトーシス / Src / TASK1 channel / endocytosis
Outline of Final Research Achievements

I investigated the function and physiological role of TASK1 channels in endocrine cells. Pharmacological and molecular biological analyses showed that TASK1 channels are regulated by the clathrin-dependent endocytosis in NGF- and muscarine-stimulated adrenal medullary and PC12 cells. Additionally, it showed that the molecular mechanisms regulating channel endocytosis differ between NGF-induced endocytosis and muscarine-induced endocytosis. The AM cells prepared from TASK1 KO mice indicated the decrease of pH sensitivity and adrenaline secretion, suggesting TASK1 channels play an important role in a sensor of acidosis and adrenaline secretion in AM cells.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Functional interaction between BDNF and mGluR II in vitro: BDNF down-regulated mGluR II gene expression and an mGluR II agonist enhanced BDNF-induced BDNF gene expression in rat cerebral cortical neurons2017

    • Author(s)
      Suzukia S, Koshimizu H, Adachi N, Matsuoka H, Fushimi S, Ono J, Ohta K, Mikia T.
    • Journal Title

      Peptides

      Volume: 21 Pages: 42-49

    • DOI

      10.1016/j.peptides.2017.01.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] GABA signaling and neuroactive steroids in adrenal medullary chromaffin cells2016

    • Author(s)
      Harada K, Matsuoka H, Fujihara H, Ueta Y, Yanagawa Y, Inoue M
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 18 Pages: 100-100

    • DOI

      10.3389/fncel.2016.00100

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Src mediates endocytosis of TWIK-related acid-sensitive K+ 1 channels in PC12 cells in response to nerve growth factor2015

    • Author(s)
      Matsuoka H and Inoue M
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 309 Issue: 4 Pages: 251-263

    • DOI

      10.1152/ajpcell.00354.2014

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of muscarinic receptor subtypes involved in catecholamine secretion in adrenal medullary chromaffin cells by genetic deletion.2015

    • Author(s)
      Harada K, Matsuoka H, Miyata H, Matsui M, Inoue M
    • Journal Title

      Br. J. Pharmacol.

      Volume: 172 Issue: 5 Pages: 1348-1359

    • DOI

      10.1111/bph.13011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fluorescent visualisation of the hypothalamic oxytocin neurones activated by cholecystokinin-8 in rats expressing c-fos-enhanced green fluorescent protein and oxtocin-monomeric red fluorescent protein 1 fusion transgenes.2014

    • Author(s)
      Katoh, A. Shoguchi, K. Matsuoka, H. Yoshimura, M. Ohkubo,JI. Matsuura, T. Maruyama, T. Ishikura, T. Aritomi, T. Fujihara, H. Hashimoto, H. Suzuki, H. Murphy, D. & Ueta, Y.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 26(5) Issue: 5 Pages: 341-347

    • DOI

      10.1111/jne.12150

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Molecular mechanism for NGF-induced endocytosis of TASK1 channels in rat adrenal medullary cells and PC12 cells2016

    • Author(s)
      Matsuoka H and Inoue M
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 副腎髄質細胞およびPC12 細胞におけるTASK1チャネルエンドサイトーシスの分子機構2015

    • Author(s)
      松岡秀忠、原田景太、井上真澄
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会 合同大会
    • Place of Presentation
      兵庫県神戸市 神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Src mediates endocytosis of TWIK-related acid-sensitive K+ channels in PC12 cells in response to nerve growth factor.2014

    • Author(s)
      Hidetada Matsuoka and Masumi Inoue
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Walter E. Washington Convention Center, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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