Elucidation of macropinocytosis-mediated neural circuit formation
| Project/Area Number |
26460309
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kabayama Hiroyuki 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (10332339)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | マクロピノサイトーシス / 膜動態 / syntaxin1B / IP3R / 反発性軸索誘導 / 神経回路形成 / syntaxin / エンドサイトーシス / 成長円錐 / 成長円錐退縮 |
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| Outline of Final Research Achievements |
During development, a repulsive axon guidance cue semaphorin 3A (sema3A)-induced growth cone collapse is caused by macropinocytosis-mediated membrane retrieval. I have identified syntaxin1B as negative regulator of macropinocytosis in growth cones. In this study, I focused on the molecular mechanism of syntaxin1B-mediated macropinocytosis and found that syntaxin1B regulates the function of IP3R1 by binding with coiled-coil domain of IP3R1, thereby mediating Ca2+-dependent macropinocytosis.
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Report
(4 results)
Research Products
(2 results)
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[Presentation] Macropinocytosis mediates Sema3A-induced growth cone collapse2014
Author(s)
Kabayama Hiroyuki, Takeuchi Makoto, Taniguchi Masahiko, Tokushige Naoko, Kozaki Shunji, Mizutani Akihiro, Hirohide Iwasaki, Nakamura Takeshi, and Mikoshiba Katsuhiko
Organizer
Calcium Signaling: from basic to bedside 2014
Place of Presentation
Stockholm, Sweden
Year and Date
2014-07-03 – 2014-07-05
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