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Elucidation of macropinocytosis-mediated neural circuit formation

Research Project

Project/Area Number 26460309
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General physiology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Kabayama Hiroyuki  国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (10332339)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsマクロピノサイトーシス / 膜動態 / syntaxin1B / IP3R / 反発性軸索誘導 / 神経回路形成 / syntaxin / エンドサイトーシス / 成長円錐 / 成長円錐退縮
Outline of Final Research Achievements

During development, a repulsive axon guidance cue semaphorin 3A (sema3A)-induced growth cone collapse is caused by macropinocytosis-mediated membrane retrieval. I have identified syntaxin1B as negative regulator of macropinocytosis in growth cones. In this study, I focused on the molecular mechanism of syntaxin1B-mediated macropinocytosis and found that syntaxin1B regulates the function of IP3R1 by binding with coiled-coil domain of IP3R1, thereby mediating Ca2+-dependent macropinocytosis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2017 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Parkin promotes proteasomal degradation of synaptotagmin IV by accelerating polyubiquitination.2017

    • Author(s)
      Kabayama, H., Tokushige, N., Takeuchi, M., Kabayama, M., Fukuda M. and Mikoshiba, K.
    • Journal Title

      Mol. Cell. Neurosci.

      Volume: 80 Pages: 89-99

    • DOI

      10.1016/j.mcn.2017.02.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Macropinocytosis mediates Sema3A-induced growth cone collapse2014

    • Author(s)
      Kabayama Hiroyuki, Takeuchi Makoto, Taniguchi Masahiko, Tokushige Naoko, Kozaki Shunji, Mizutani Akihiro, Hirohide Iwasaki, Nakamura Takeshi, and Mikoshiba Katsuhiko
    • Organizer
      Calcium Signaling: from basic to bedside 2014
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-07-03 – 2014-07-05
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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