Research on anticancer drug target that regulate two types of cell death, necrosis and apoptosis
Project/Area Number |
26460310
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | Tokyo University of Science |
Principal Investigator |
Sato Akira 東京理科大学, 薬学部薬学科, 講師 (40530663)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ネクローシス / アポトーシス / マイクロRNA / 細胞死制御因子 / プロテオミクス / 全エクソンシークエンス / がん分子標的 / 核酸化学 / 細胞外漏出タンパク質 / 細胞死関連遺伝子変異 / ショットガンプロテオミクス / 核酸医薬 / 細胞死制御 / 腫瘍内壊死 / MicroRNA / Lamin-B1 / Cytokeratin-19 / ATF3 |
Outline of Final Research Achievements |
We aimed to find and characterize anticancer target(s) in regulators of cell death-mode, necrosis or apoptosis, by genomic and proteomic approach. (1) Extracellular leaked proteins in necrosis or apoptosis were detected by proteomic approach; (2) Gene mutations related cell-death switching were found by whole exon sequencing; (3) We investigated the anticancer effectiveness for the previously reported cell-death regulators, and identified a possible anticancer microRNA.
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] MicroRNA-351 regulates two-types of cell death, necrosis and apoptosis, induced by 5-fluoro-2’-deoxyuridine2016
Author(s)
Sato A., Omi T., Yamamoto A., Satake A., Hiramoto A., Masutani M., Tanuma S., Wataya Y., Kim H.-S.
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Journal Title
PLOS ONE
Volume: 11
Issue: 4
Pages: e0153130-e0153130
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells2015
Author(s)
Sakagami H., Shimada C., Kanda Y., Amano O., Sugimoto M., Ota S., Soga T., Tomita M., Sato A., Tanuma S., Takao K., Sugita Y.
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Journal Title
Toxicology Reports
Volume: 2
Pages: 1281-1290
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Proteomic analysis of cellular response induced by boron neutron capture reaction in human squamous cell carcinoma SAS cells2015
Author(s)
Sato A., Itoh T., Imamichi S., Kikuhara S., Fujimori H., Hirai T., Saito S., Sakurai Y., Tanaka H., Nakamura H., Suzuki M., Murakami Y., Baiseitov D., Berikkhanova K., Zhumadilov Z., Imahori Y., Itami J., Ono K., Masunaga S., Masutani M.
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Journal Title
Applied Radiation and Isotopes
Volume: 106
Pages: 113-219
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] An early inflammatory and immune cascade activation after BNCR in human cancer cells2016
Author(s)
Mitsuko Masutani, Shoji Imamichi, Tasuku Itoh, Akira Sato, Sota Kikuhara, Hiroaki Fujimori, Yasuhito Arai, Yasufumi Murakami, Jun Itami, Minoru Suzuki, Koji Ono, Yoshinori Sakurai, Hiroaki Tanaka, Shinichiro Masunaga.
Organizer
17th International Congress on Neutron Capture Therapy
Place of Presentation
University of Missouri, Columbia, Missouri, USA
Year and Date
2016-10-02
Related Report
Int'l Joint Research
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[Presentation] ホウ素中性子捕捉反応(BNCR)後の細胞応答の解析とバイオマーカーの探索と同定2016
Author(s)
益谷美都子, 今道祥二, 佐藤 聡, 伊藤 祐, 菊原颯太, 藤森 浩彰, 平井崇久, 新井康仁, 櫻井良憲, 田中浩基, 岡本裕之, 今堀良夫, 村上康文, 伊丹 純, 中村浩之, 鈴木 実, 小野公二, 増永慎一郎.
Organizer
2016第45回放射線による制癌シンポジウム・第54回日本放射線腫瘍学会生物部会学術大会
Place of Presentation
I-siteなんば(大阪府大阪市)
Year and Date
2016-07-15
Related Report
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[Presentation] BNCTに対するがん細胞応答の網羅的遺伝子発現解析及びプロテオーム解析2016
Author(s)
今道祥二, 佐藤 聡, 伊藤 祐, 菊原颯太, 藤森浩彰, 平井崇久, 新井康仁, 今堀 良夫, 伊丹 純, 村上康文, 鈴木 実, 小野公二, 櫻井良憲, 田中浩基, 増永慎一郎, 益谷美都子.
Organizer
第18回癌治療増感研究シンポジウム
Place of Presentation
奈良県文化会館(奈良、奈良)
Year and Date
2016-02-05
Related Report
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[Presentation] BNCTに対するがん細胞応答の網羅的解析―CSF2、HMGB1の動態及び細胞外変動因子の解析2015
Author(s)
今道 祥二, 佐藤 聡, 伊藤 祐, 菊原 颯太, 藤森 浩彰, 平井 崇久, 新井 康仁, 今堀 良夫, 伊丹 純, 村上 康文, 小野 公二, 櫻井 良憲, 田中 浩基, 増永 慎一郎, 益谷 美都子.
Organizer
第12回日本中性子捕捉療法学会学術大会
Place of Presentation
神戸学院大学ポートアイランドキャンパス(兵庫、神戸)
Year and Date
2015-09-04
Related Report
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[Presentation] The response of cancer cells to boron neutron capture reaction2015
Author(s)
Shoji Imamichi, Tasuku Itoh, Akira Sato, Sota Kikuhara, Hiroaki Fujimori, Takahisa Hirai, Yasuhito Arai, Yasufumi Murakami, Yoshio Imahori, Jun Itami, Koji Ono, Yoshinori Sakurai, HiroakiTanaka, Shinichiro Masunaga, Mitsuko Masutani.
Organizer
15th International Congress of Radiation Research 第15回国際放射線研究会議 (ICRR2015)
Place of Presentation
京都国際会館(京都、京都)
Year and Date
2015-05-25
Related Report
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[Presentation] BNCTに対する口腔がん及び悪性黒色種細胞株の応答性の検討2014
Author(s)
今道祥二,伊藤 祐, 佐藤 聡,菊原颯太, 藤森浩彰, 平井崇久, 新井康仁, 今堀良夫 伊丹 純,村上康文, 小野公二, 増永慎一郎, 益谷美都子.
Organizer
第73回日本癌学会学術総会
Place of Presentation
パシフィコ横浜 (神奈川県)
Year and Date
2014-09-25 – 2014-09-27
Related Report
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[Presentation] BNCTに対するがん細胞応答の網羅的遺伝子発現解析及びプロテオーム解析2014
Author(s)
今道祥二, 佐藤 聡, 伊藤 祐, 菊原颯太, 藤森浩彰, 平井崇久, 今堀良夫, 伊丹 純, 村上康文, 小野公二, 櫻井良憲, 田中浩基, 増永慎一郎, 益谷美都子.
Organizer
第11回日本中性子捕捉療法学会学術大会
Place of Presentation
大阪大学吹田キャンパスコンベンションセンター(大阪府)
Year and Date
2014-07-05 – 2014-07-06
Related Report
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[Presentation] Analysis of cell-death response and DAMPs after boron neutron capture reaction in human cancer cells2014
Author(s)
Akira Sato, Tasuku Itoh, Hiroaki Fujimori, Takahisa Hirai, Soichiro Saito, Yasuhito Arai, Yasufumi Murakami, Yoshio Imahori, Jun Itami, Hiroyuki Nakamura, Minoru Suzuki, Koji Ono, Shinichiro Masunaga, Mitsuko Masutani.
Organizer
16th International Congress on Neutron Capture Therapy
Place of Presentation
Porssitalo (Helsinki, Finland)
Year and Date
2014-06-14 – 2014-06-19
Related Report
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