Analysis of respiratory rhythm generation triggered by medullary astrocytes
| Project/Area Number |
26460311
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | National Hospital Organization Murayama Medical Center |
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Principal Investigator |
Okada Yasumasa 独立行政法人国立病院機構村山医療センター(臨床研究部), 電気生理学研究室, 室長 (80160688)
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| Research Collaborator |
ONIMARU Hiroshi
YAZAWA Itaru
OKAZAKI Shuntaro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 呼吸調節 / 呼吸リズム形成 / 低酸素呼吸応答 / 脳幹 / 延髄 / グリア細胞 / アストロサイト / カルシウムイメージング / ニューロン / 呼吸リズム / 低酸素 / 換気応答 / arundic acid / 短期増強 |
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| Outline of Final Research Achievements |
Continuously generated respiratory rhythm is essential to maintain life. However, the mechanism of respiratory rhythm generation has not been fully elucidated. Recent advances in glial physiology have indicated that glia cells especially astrocytes play important roles in various brain functions. To clarify the role of astrocytes in respiratory control, we analyzed activities of neurons and astrocytes in the ventrolateral medulla in the isolated brainstem spinal cord preparation of neonatal rats by calcium imaging, and found respiratory modulated astrocytes that were spontaneously oscillatory even in the absence of neuronal activity. In unanesthetized mice, ventilatory responses to hypoxia were attenuated in the presence of arundic acid that inhibits astrocytic activation. These findings suggest that astrocytes play vital roles in central respiratory control in particular in respiratory rhythm generation as pacemaker cells and in hypoxic respiratory responses as hypoxic sensor cells.
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Report
(4 results)
Research Products
(32 results)
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[Presentation] A novel model of respiratory rhythm generation: a mechanism by interaction of intrinsically oscillating astrocytes and neurons2015
Author(s)
Okada Y, Oku Y, Sasaki T, Vivar C, Yokota S, Takeda K, Fukushi I, Yazawa I, Someya H, Tamura Y
Organizer
Neuroscience 2015, 45th Society for Neuroscience Annual Meeting
Place of Presentation
Chicago, USA
Year and Date
2015-10-17
Related Report
Int'l Joint Research
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