| Project/Area Number |
26460316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Nippon Medical School (2015-2016)
Gunma University (2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松崎 利行 群馬大学, 大学院医学系研究科, 教授 (30334113)
飯島 典生 日本医科大学, 医学部, 准教授 (00285248)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | kisspeptin / neurokinin B / prolactin / thyroliberin / sex hormone / network / receptor expression / hypothalamus / axonal projection / 甲状腺刺激ホルモン放出ホルモン / キスペプチン / 室傍核 / kisspeptin receptor / NPFF receptor / ニューロキニンB |
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| Outline of Final Research Achievements |
Kisspeptin expressing neuron in the hypothalamus of the brain, is recently well known as a center of rhythm formation in sex hormone cycle. In the present study, we identified a neural network that may convey an effect of kisspeptin to prolactin regulating dopaminergic neuron or thyroliberin producing neuron, which is called TRH neuron, that also regulates body temperature. The finding suggests a possibility that kisspeptin affect via TRH, to the changes of prolactin secretion or body temperature that occur during pregnancy, delivery, or menopause.
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