Neuroinfammation induced by systemic stress and plasmalogen
| Project/Area Number |
26460320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | プラズマローゲン / オーファンG蛋白共役型受容体 / 海馬 / NF-κB / リポポリサッカライド / ショートヘアピンRNA / 水迷路学習 / 神経新生 / 神経炎症 / プラズマローゲン合成酵素 / c-myc / 脳由来神経栄養因子 / 学習機能 / アルツハイマー病 / ミクログリア / G蛋白結合型受容体 / shRNA / Akt / CREB / 血液脳関門 / レンチウイルス / BDNF |
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| Outline of Final Research Achievements |
(1) We found that the plasmalogen (Pls)-induced activation of protein kinases was mediated by at least 5 orphan G-protein-coupled receptors (GPCRs), GPR1, GPR19, GPR21, GPR27 and GPR61 using knockdown and overexpression cells (PLoS ONE, 11: e0150846, 2016). (2) We found that inflammatory stimuli reduced Pls contents by downregulation of Pls synthesizing enzyme, GNPAT, through the NF-κB-mediated recruitment of c-Myc onto the GNPAT promoter in both murine and human cell lines. (J Neurosci, 37 (15): 4074-4092, 2017). (3) Knock down of GNPAT in the mouse hippocampus impaired spatial memory and decreased brain-derived neurotrophic factor (BDNF) expression. Pls-containing diet in mice increased hippocampal Pls, enhanced spatial memory with high expressions of phosphorylated (p-) Akt, p-CREB and BDNF along with enhanced hippocampal neurogenesis, spine formation, and long term potentiation. (in submission).
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Reduction of ether-type glycerophospholipids, plasmalogens, by NF-κB signal leading to microglial activation2017
Author(s)
Hossain, Md. S., Abe, Y., Ali, F., Youssef, M., Honsho, M., Fujiki, Y., and *Katafuchi, T.
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Journal Title
J. Neurosci.
Volume: 37
Issue: 15
Pages: 4074-4092
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effects of 3,3',5-triiodothyronine on microglial functions2015
Author(s)
Mori Y, Tomonaga D, Kalashnikova A, Furuya F, Akimoto N, Ifuku M, Okuno Y, Beppu K, Fujita K, Katafuchi T, Shimura H, Churilov LP, Noda M
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Journal Title
Glia
Volume: 63(5)
Issue: 5
Pages: 906-920
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 心と体の疲労：基礎からの理解．2015
Author(s)
片渕俊彦
Organizer
第54回日本心身医学会九州地方会
Place of Presentation
九州工業大学大学院生命体工学研究科（北九州市）
Year and Date
2015-01-24 – 2015-01-25
Related Report
Invited
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