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Blood flow regulatio in vertebral artery.

Research Project

Project/Area Number 26460324
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionJapan Women's College of Physical Education

Principal Investigator

SATO Kohei  日本女子体育大学, 体育学部, 准教授 (00409278)

Co-Investigator(Kenkyū-buntansha) 定本 朋子  日本女子体育大学, 体育学部, 教授 (30201528)
小河 繁彦  東洋大学, 理工学部, 教授 (80553841)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords椎骨動脈 / 低形成 / 不活動 / 脳血流調節 / 姿勢変化 / 動的血流調節 / 運動 / 椎骨静脈 / 中枢性疲労 / ベッドレスト / 動的血流調節機能 / 高炭酸 / 過呼吸
Outline of Final Research Achievements

Recent studies have suggested that vertebral artery (VA) hypoplasia is a predisposing factor for posterior cerebral stroke. We examined whether anatomical vertebrobasilar ischemia, i.e., unilateral VA hypoplasia and insufficiency, impairs dynamic blood flow regulation. Twenty-eight female subjects were divided into three groups by defined criteria: 1) unilateral VA hypoplasia (N = 8), 2) VA insufficiency (N = 6), and 3) control (N = 14). We evaluated left, right, and net VA blood flows by ultrasonography during hypercapnia, normocapnia, and hypocapnia to evaluate VA CO2 reactivity. In this tudy, VA hypoplasia reduced CO2 reactivity, although non-hypoplastic VA may compensate this regulatory limitation. In subjects with VA insufficiency, lowered CO2 reactivity at the both VA could not preserve normal net VA CO2 reactivity. Our findings provide important information regarding anatomical risk for stroke and ischemia in posterior cerebral circulation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (4 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] ヨーロッパ宇宙機構(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ヨーロッパ宇宙開発機構/ドイツ航空宇宙局(ドイツ)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] カン大学(フランス)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] 西オンタリオ大学(カナダ)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Relationship between cerebral arterial inflow and venous outflow during dynamic supine exercise2017

    • Author(s)
      Sato K, Oba N, Washio T, Sasaki H, Oue A, Otsuki Aki, Sadamoto T, Ogoh S.
    • Journal Title

      Physiological Reports

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Coupling between arterial and venous cerebral blood flow during postural change.2016

    • Author(s)
      Ogoh S, Washio T, Sasaki H, Petersen LG, Secher NH, Sato K.
    • Journal Title

      American Journal of Physiology

      Volume: 311(6) Issue: 6 Pages: 1255-1261

    • DOI

      10.1152/ajpregu.00325.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Heat stress redistributes blood flow in arteries of the brain during dynamic exercise2016

    • Author(s)
      Sato K, Oue A, Yoneya M, Sadamoto T, Ogoh S.
    • Journal Title

      J Appl Physiol (1985)

      Volume: 120 Issue: 7 Pages: 766-773

    • DOI

      10.1152/japplphysiol.00353.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Internal carotid and vertebral arteries blood flow during graded lower body negative pressure in humans2015

    • Author(s)
      Sigehiko Ogoh, Kohei Sato, Kazunobu Okazaki, Tadayoshi Miyamoto, Ai Hirasawa, Tomoko Sadamoto, Manabu Shibasaki.
    • Journal Title

      Experimantal Physiology

      Volume: Mar;100(3) Issue: 3 Pages: 259-66

    • DOI

      10.1113/expphysiol.2014.083964

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Anatomical vertebral artery hypoplasia and insufficiency impairs dynamic blood flow regulation2014

    • Author(s)
      Kohei Sato, Marina Yoneya, Aki Ohtsuki, Tomoko Sadamoto, Shigehiko Ogoh.
    • Journal Title

      Clin Physiol Funct Imaging

      Volume: Jun 30 Issue: 6 Pages: 12179-12179

    • DOI

      10.1111/cpf.12179

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Book] ニュー運動生理学Ⅱ section11-5 脳血流2014

    • Author(s)
      佐藤 耕平 (宮村 実晴編集)
    • Total Pages
      9
    • Publisher
      真興交易医書出版
    • Related Report
      2014 Research-status Report
  • [Remarks] 日本女子体育大学 基礎体力研究所HP

    • URL

      http://www.jwcpe.ac.jp/research/

    • Related Report
      2015 Research-status Report
  • [Remarks] 日本女子体育大学基礎体力研究所

    • URL

      http://www.jwcpe.ac.jp/research/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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