| Project/Area Number |
26460325
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
Akema Tatsuo 聖マリアンナ医科大学, 医学部, 名誉教授 (60128585)
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| Co-Investigator(Kenkyū-buntansha) |
藤原 清悦 聖マリアンナ医科大学, 医学部, 講師 (10440322)
黒坂 光寿 聖マリアンナ医科大学, 医学部, 助教 (40553970)
舩橋 利也 聖マリアンナ医科大学, 医学部, 教授 (70229102)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ミクログリア / 海馬 / 学習 / シナプス / 行動解析 / 行動 / 生化学 / AMPA受容体 / 消去 / 可塑性 / 再固定 / グルタミン酸受容体 / AMPA受容体サブユニット / ミノサイクリン / 受動的回避学習 / Wistar雄性ラット / GluR1サブユニット |
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| Outline of Final Research Achievements |
Microglia specific inhibitor, minocycline was administered before and after passive avoidance task in male rats. As the results, minocycline injection shortened the time enter the dark box. This means that the blocking of microglia activation attenuated the establishment of bad memory formation. We also analyzed AMPA receptor subunit expression. We revealed that phosphorylation status of 845 serine thus PKA might be changed. Next, we examined this task in mice. In mice, minocycline injection might attenuate the reconsolidation process hereby long-term bad memory formation was attenuated.
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