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The physiological role of pain-induced dopamine release within the nucleus accumbens in affections

Research Project

Project/Area Number 26460330
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionTokyo Metropolitan Institute of Medical Science (2015-2016)
Hokkaido University (2014)

Principal Investigator

IDE Soichiro  公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (30389118)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords側坐核 / ドパミン / 痛み / 報酬 / うつ / 負情動 / 嫌悪 / 薬理学 / 情動
Outline of Final Research Achievements

In the present study, we examined the physiological role of pain-induced dopamine release within the nucleus accumbens in pain-induced aversion. A significant increase in the dopamine level and increased neuronal activity within the rostral part of the nucleus accumbens shell were caused by the acetic acid intraperitoneal injection. The conditioned place aversion (CPA) induced by the acetic acid intraperitoneal injection was abolished in dopamine transporter knockout mice. Further, reward-induced dopamine release in the nucleus accumbens of neuropathic pain rats were investigated. Pain relief and sucrose solution were given to the neuropathic pain rats as rewards. Rewards increased dopamine release in the early, but not late, phase of pain. Dysfunction of the mesolimbic dopamine reward circuit might be a common neuronal mechanism underlying chronic pain and depression and a potential target to develop novel analgesic and antidepressant medications.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015 2014 Other

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Distinct roles of opioid and dopamine systems in lateral hypothalamic intracranial self-stimulation.2017

    • Author(s)
      Ide S, Takahashi T, Takamatsu Y, Uhl G, Niki H, Sora I, Ikeda K
    • Journal Title

      Int J Neuropsychopharmacol

      Volume: 印刷中 Pages: pyw113-pyw113

    • DOI

      10.1093/ijnp/pyw113

    • NAID

      120006373767

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Loss of GluN2D subunit results in social recognition deficit, social stress, 5-HT2C receptor dysfunction, and anhedonia in mice.2017

    • Author(s)
      Yamamoto H, Kamegaya E, Hagino Y, Takamatsu Y, Sawada W, Matsuzawa M, Ide S, Yamamoto T, Mishina M, Ikeda K
    • Journal Title

      Neuropharmacology

      Volume: 112(Pt A) Pages: 188-197

    • DOI

      10.1016/j.neuropharm.2016.07.036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pain relief induces dopamine release in the rat nucleus accumbens during the early but not late phase of neuropathic pain.2016

    • Author(s)
      Kato T., Ide S., Minami M.
    • Journal Title

      Neurosci. Lett.

      Volume: 629 Pages: 73-78

    • DOI

      10.1016/j.neulet.2016.06.060

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of adenylate cyclase-cyclic AMP-protein kinase A signaling by corticotropin-releasing factor within the dorsolateral bed nucleus of the stria terminalis is involved in pain-induced aversion.2016

    • Author(s)
      Kaneko T, Kaneda K, Ohno A, Takahashi D, Hara T, Amano T, Ide S, Yoshioka M, Minami M
    • Journal Title

      Eur. J. Neurosci.

      Volume: 44 Issue: 11 Pages: 2914-2924

    • DOI

      10.1111/ejn.13419

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] How does pain induce negative emotion? Role of the bed nucleus of the stria terminalis in pain-induced place aversion.2015

    • Author(s)
      Minami M, Ide S.
    • Journal Title

      Curr. Mol. Med.

      Volume: 15 Pages: 184-190

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amelioration of the reduced antinociceptive effect of morphine in the unpredictable chronic mild stress model mice by noradrenalin but not serotonin reuptake inhibitors.2015

    • Author(s)
      Ide S, Satoyoshi H, Minami M, Satoh M.
    • Journal Title

      Mol. Pain

      Volume: 11 Pages: 47-47

    • DOI

      10.1186/s12990-015-0051-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corticotropin-releasing factor enhances inhibitory synaptic transmission to type III neurons in the bed nucleus of the stria terminalis.2015

    • Author(s)
      Nagano Y, Kaneda K, Maruyama C, Ide S, Kato F, Minami M
    • Journal Title

      Neurosci. Lett.

      Volume: 600 Pages: 56-61

    • DOI

      10.1016/j.neulet.2015.05.059

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] How does pain induce negative emotion? Role of the bed nucleus of the stria terminalis in pain-induced place aversion.2015

    • Author(s)
      Minami M, Ide S.
    • Journal Title

      Curr Mol Med.

      Volume: 15 Pages: 184-190

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 38.脳内自己刺激法を用いた薬物依存性解析および報酬系神経回路の解析2016

    • Author(s)
      井手聡一郎, 池田和隆
    • Organizer
      第51回日本アルコール・アディクション医学会学術総会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 23.The abolished rewarding effect of methylphenidate in dopamine transporter knockout mice, a model for attention deficit/hyperactivity disorder2016

    • Author(s)
      IDE S, TAKAMATSU Y, IKEKUBO Y, TAKEDA TC, NAGASAWA S, HUA J, IKEDA K
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      COEX (韓国・ソウル)
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経障害性疼痛モデルラットにおける報酬誘発性側坐核内ドパミン遊離の時期依存的変調2016

    • Author(s)
      加藤貴大、井手聡一郎、南雅文
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川・横浜)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 慢性疼痛による側坐核内ドパミン遊離変化解析2015

    • Author(s)
      加藤貴大、井手聡一郎、南雅文
    • Organizer
      第35回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      和歌山県立情報交流センターBig・U(和歌山・田辺)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] オピオイド鎮痛薬鎮痛効果への慢性ストレスの影響2014

    • Author(s)
      里吉寛、井手聡一郎、佐藤公道、南雅文
    • Organizer
      第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会 合同年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2014-11-20 – 2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] GABAトランスポーターサブタイプ特異的な新規阻害薬候補化合物の薬理活性評価2014

    • Author(s)
      井川ありさ、佐藤孝行、末政亮大、小林嵩明、有澤光弘、井手聡一郎、周東智、南雅文
    • Organizer
      第65回日本薬理学会北部会
    • Place of Presentation
      コラッセふくしま
    • Year and Date
      2014-09-26 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Remarks] 東京都医学総合研究所 依存性薬物プロジェクトホームページ

    • URL

      http://www.igakuken.or.jp/abuse/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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