Molecular bases for intracellular trafficking and functional signalosome formation mediated through histamine H3 receptor
Project/Area Number |
26460331
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General pharmacology
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Research Institution | Tohoku University |
Principal Investigator |
Sukegawa Jun 東北大学, 医学系研究科, 非常勤講師 (30187687)
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Co-Investigator(Kenkyū-buntansha) |
柳澤 輝行 東北福祉大学, 健康科学部, 教授 (90133941)
佐藤 岳哉 東北大学, 医学系研究科, 准教授 (10312696)
斎藤 将樹 東北大学, 医学系研究科, 助教 (50400271)
倉増 敦朗 山口大学, 医学(系)研究科(研究院), 准教授 (90302091)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | Gタンパク質共役型受容体 / ヒスタミンH3受容体 / カルボキシル末端 / シグナロソーム / 膜輸送 / ユビキチン化 / Rab8 / 細胞内輸送 / サイクリックAMP / Gタンパク質共役型受容体 |
Outline of Final Research Achievements |
Through direct interactions with G protein-coupled receptors, various proteins regulate cellular distribution and signal transduction of the receptors. The protein complex is so called “signalosome”. In the present study, we investigated roles of DRiP78 and Rab8, as examples of signalosome molecules, in functions of histamine H3 receptor with the central focus on the receptor’s cellular distribution. We found that DRiP78 and Rab8 are involved in reduction and increase in plasma membrane distribution of the receptor, respectively.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity.2015
Author(s)
Murakami M, Yoshikawa T, Nakamura T, Ohba T, Matsuzaki Y, Sawamura D, Kuwasako K, Yanagisawa T, Ono K, Nakaji S, Yanai K.
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Journal Title
Biochem Biophys Res Commun.
Volume: 458
Issue: 3
Pages: 584-589
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases2015
Author(s)
Suzuki T, Yamaguchi H, Kikusato M, Matsuhashi T, Matsuo A, Sato T, Oba Y, Watanabe S, Minaki D, Saigusa D, Shimbo H, Mori N, Mishima E, Shima H, Akiyama Y, Takeuchi Y, Yuri A, Kikuchi K, Toyohara T, Suzuki C, Kohzuki M, Anzai J, Mano N, Kure S, Yanagisawa T, Tomioka Y, Toyomizu M, Ito S, Osaka H, Hayashi K, Abe T
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 236
Issue: 3
Pages: 225-232
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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