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Role of sphingosine 1-phosphate signaling on tumor metastasis

Research Project

Project/Area Number 26460341
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionKobe University

Principal Investigator

Kajimoto Taketoshi  神戸大学, 大学院医学研究科, 助教 (00509953)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords生理活性物質 / シグナル伝達 / エクソソーム / スフィンゴシン1-リン酸 / スフィンゴシンキナーゼ / 癌 / スフィンゴシン-1-リン酸 / スフィンゴシン-1-リン酸受容体 / 癌転移
Outline of Final Research Achievements

Exosomes are small membrane-bound vesicles released from a variety of physiological cells or tumor cells and include much functional proteins and RNAs as cargo. Recently we discovered new mechanism of Sphingosine 1-phosphate (S1P) signaling-regulated cargo sorting into exosomes. However the role of S1P signaling on sorting of cargoes that relates to tumor metastasis such as c-Met or miRNA into exosomes is still unclear. Here, we found S1P-signaling also plays a critical role in exosomal sorting of these tumor metastasis-related cargoes. Now we continue to try some in vitro study to figure out the importance of S1P signaling-induced exosomal cargo sorting on tumor metastasis. If completing this study we would expect that S1P signaling becomes innovative drug target for tumor metastasis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015 2014 Other

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] Extracellular α-synuclein induces sphingosine 1-phosphate receptor subtype 1 uncoupled from inhibitory G-protein leaving β-arrestin signal intact.2017

    • Author(s)
      Zhang L, Okada T, Badawy SM, Hirai C, Kajimoto T, Nakamura SI.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 44248-44248

    • DOI

      10.1038/srep44248

    • NAID

      120006380401

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Impairment of PDGF-induced chemotaxis by extracellular α-synuclein through selective inhibition of Rac1 activation2016

    • Author(s)
      Okada, T., Hirai, C., Badawy, S., Zhang, L., Kajimoto, T., Nakamura, SI.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 37810-37810

    • DOI

      10.1038/srep37810

    • NAID

      120005898707

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] エキソソームの形成機構2015

    • Author(s)
      梶本 武利、岡田 太郎、中村 俊一
    • Journal Title

      細胞工学

      Volume: Vol.34 No.2 Pages: 168-173

    • Related Report
      2014 Research-status Report
  • [Presentation] Sphingosine 1-phosphate signaling on multivesicular endosome triggers sorting of protein cargo into exosomes2015

    • Author(s)
      Taketoshi Kajimoto*, Taro Okada, Satoshi Miya, Lifang Zhang, Shun-ichi Nakamura
    • Organizer
      2015 ASCB Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of S1P signaling on cargo loading for exosome maturation2015

    • Author(s)
      Taketoshi Kajimoto*, Shun-ichi Nakamura
    • Organizer
      University of Washington-Kobe University Symposium on Cell Signaling
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Sphingosine 1-phosphate signaling triggers exosomal protein sorting2014

    • Author(s)
      梶本 武利、岡田 太郎、宮 聡志、○張 麗芳、中村 俊一
    • Organizer
      神戸大学・ワシントン大学国際合同シンポジウム
    • Place of Presentation
      神戸、日本
    • Year and Date
      2014-12-15 – 2014-12-16
    • Related Report
      2014 Research-status Report
  • [Presentation] エクソソームへの積み荷ソーティングにおける生理活性物質スフィンゴシン1-リン酸の役割2014

    • Author(s)
      ○梶本 武利、岡田 太郎、宮 聡志、張 麗芳、中村 俊一
    • Organizer
      第118回 日本薬理学会近畿部会
    • Place of Presentation
      岡山、日本
    • Year and Date
      2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] スフィンゴシン1-リン酸シグナリングによるエクソソームへの積み荷ソーティング機構2014

    • Author(s)
      ○梶本 武利、岡田 太郎、宮 聡志、張 麗芳、中村 俊一
    • Organizer
      第66回 日本細胞生物学会大会
    • Place of Presentation
      奈良、日本
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Sphingosine 1-phosphate signaling regulates exosomal cargo sorting2014

    • Author(s)
      ○梶本 武利、岡田 太郎、宮 聡志、張 麗芳、中村 俊一
    • Organizer
      2014 ASBMB Annual Meeting(アメリカ生化学・分子生物学会大会)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Research-status Report
  • [Remarks] 神戸大学大学院医学研究科生化学・分子生物学講座生化学分野

    • URL

      http://www.med.kobe-u.ac.jp/biochemistry/Home.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 神戸大学 医学研究科 中村研究室

    • URL

      http://www.med.kobe-u.ac.jp/biochemistry/Home.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-01-07  

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