New therapeutic strategy for brain-cardiorenal-glucose metabolism syndrome: targeting on the sympathetic nervous system and SGLT2
| Project/Area Number |
26460343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生活習慣病 / 肥満 / 糖尿病 / 腎臓病 / レニンアンジオテンシン系 / SGLT2 / インスリン抵抗性 / 血圧 / 臓器連関 / 高血圧 / 交感神経 / レニン・アンジオテンシン系 / メタボリックシンドローム |
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| Outline of Final Research Achievements |
We aimed to determine the potential roles of sympathetic nervous system, renin-angiotensin system and SGLT2 in the pathophysiology of brain-cardiorenal-glucose metabolism syndrome during the development of obese and diabetes. Our data have shown that during the development of obese and diabetes, 1) the brain-cardiorenal-glucose metabolism syndrome is exists, 2) sympathetic nervous system and intrarenal renin-angiotensin system and SGLT2 play an important role in the pathogenesis of brain-cardiorenal-glucose metabolism syndrome, 3) brain-cardiorenal-glucose metabolism syndrome contributes to the progression of diabetes cardiovascular and renal complications. These data may help to develop new strategy for diabetes cardiovascular and renal complications.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] A sodium-glucose co-transporter 2 inhibitor empagliflozin prevents abnormality of circadian rhythm of blood pressure in salt-treated obese rats.2016
Author(s)
Takeshige Y, Fujisawa Y, Rahman A, Kittkulsuth W, Nakano D, Mori H, Masaki T, Ohmori K, Kohno M, Ogata H, Nishiyama A.
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Journal Title
Hypertens. Res.
Volume: 39(6)
Issue: 6
Pages: 415-422
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Effect of dipeptidyl peptidase-4 inhibition on circadian blood pressure during the development of salt-dependent hypertension in rats.2015
Author(s)
Sufiun A, Rafiq K, Fujisawa Y, Rahman A, Mori H, Nakano D, Kobori H, Ohmori K, Masaki T, Kohno M, Nishiyama A.
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Journal Title
Hypertens Res.
Volume: 38(4)
Issue: 4
Pages: 237-243
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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