Elucidation of environmental factors involved in the onset of hyperuricemia using complete model animals of human uric acid metabolism
| Project/Area Number |
26460347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
富岡 直子 帝京大学, 薬学部, 助教 (60525814)
金子 希代子 帝京大学, 薬学部, 教授 (90147075)
関根 祐子 千葉大学, 大学院薬学研究院, 教授 (30567350)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 尿酸 |
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| Outline of Final Research Achievements |
1. Successful breeding of B6/XcMSM mice reported to have a higher HPRT activity than experimental mice such as C57BL/6 and successive breeding exceeding reproductive septa associated with subspecies differences. 2. We confirmed that B6/XcMSM mice have HPRT high activity allele and established genotyping method of HPRT allele. 3. By using B6/XcMSM mouse, suppression of hypoxanthine release by blood purinergic system with HPRT high activity was observed in blood cells without Xanthine oxidoreductase (Xor) activity. 4. UoxKO-XcMSM mouse creation enabled us to obtain mice that were close to human uric acid metabolism except that Xor was highly active.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Apoptosis induced by an uromodulin mutant C112Y and its suppression by topiroxostat.2014
Author(s)
Utami SB, Mahati E, Li P, Maharani N, Ikeda N, Bahrudin U, Munemura C, Hosoyamada M, Yamamoto Y, Yoshida A, Nakayama Y, Higaki K, Nanba E, Ninomiya H, Shirayoshi Y, Ichida K, Yamamoto K, Hosoya T, Hisatome I.
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Journal Title
Clin Exp Nephrol. 2014 Sep 20.
Volume: 00
Issue: 4
Pages: 000-0
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of a hypouricemia patient with SLC2A9 R380W, a pathogenic mutation for renal hypouricemia type 2.2014
Author(s)
Chiba T, Matsuo H, Nagamori S, Nakayama A, Kawamura Y, Shimizu S, Sakiyama M, Hosoyamada M, Kawai S, Okada R, Hamajima N, Kanai Y, Shinomiya N.
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Journal Title
Nucleosides Nucleotides Nucleic Acids.
Volume: 33
Issue: 4-6
Pages: 261-5
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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