Mg2+ regulation by SLC41 transporters and pathological mechanism for its abnormality
| Project/Area Number |
26460351
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤井 誠 福岡大学, 医学部, 講師 (30398086)
後藤 雄輔 福岡大学, 医学部, 助教 (90609489)
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| Co-Investigator(Renkei-kenkyūsha) |
KITA Satomi 福岡大学, 医学部, 准教授 (10461500)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | イオン輸送体 / マグネシウム / 病態モデル |
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| Outline of Final Research Achievements |
Cellular Mg2+ plays an important role in various cellular functions, such as energy metabolism, channel activity, and enzyme activity. Therefore, various diseases are caused by abnormal Mg2+ regulation. Recently, several Mg2+ transporters are cloned, but their functional roles are still well unknown. We first observed that the expression levels of SLC41 transporters in aorta were dependent on the Mg2+ intake (low, normal, or high). In addition, we found that phenylephrine-induced contraction was reduced in isolated aorta from low-magnesium-fed mice. Furthermore, we next generated SLC41A1/A2-knockout mice. Interestingly, phenylephrine-induced contraction was reduced in isolated aorta from SLC41A2-knockout mice fed with normal-magnesium diet. These results suggest that SLC41A1/A2 play an important role in vascular function. Further work will be required to define the pathological role of SLC41A1/A2 in cardiovascular diseases.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Na<sup>+</sup>/Ca<sup>2+</sup> exchanger contributes to stool transport in mice with experimental diarrhea2017
Author(s)
Nishiyama K, Tanioka K, Azuma YT, Hayashi S, Fujimoto Y, Yoshida N, Kita S, Suzuki S, Nakajima H, Iwamoto T, Takeuchi T.
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Journal Title
Journal of Veterinary Medical Science
Volume: 79
Issue: 2
Pages: 403-411
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access
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[Journal Article] Roles of Na+/Ca2+ exchanger isoforms NCX1 and NCX2 in motility in mouse ileum.2016
Author(s)
Nishiyama K, Azuma YT, Morioka A, Yoshida N, Teramoto M, Tanioka K, Kita S, Hayashi S, Nakajima H, Iwamoto T, Takeuchi T.
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Journal Title
Naunyn Schmiedebergs Arch Pharmacol.
Volume: 389
Issue: 10
Pages: 1081-1090
DOI
NAID
Related Report
Peer Reviewed
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