| Project/Area Number |
26460352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Kimura Yuka 国立研究開発法人国立精神・神経医療研究センター, 神経研究所, 科研費研究員 (60425692)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Hideo 国立精神, 神経医療研究センター, 研究員 (30321889)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ポリサルファイド / 硫化水素 / TRPA1 / 3-メルカプトピルビン酸イオウ転移酵素 / シグナル分子 / メルカプトピルビン酸 / 脳 / レドックス調節 / 3-メルカプトピルビン酸硫黄転移酵素 / 酵素的産生 / ロダネース / 3メルカプトピルビン酸硫黄転移酵素 / Rhodanese / 細胞内カルシウム / アストロサイト / シグナリング |
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| Outline of Final Research Achievements |
We demonstrated that hydrogen sulfide(H2S) and polysulfide (H2Sn、n≧2)are endogenous signaling molecules. In the present study, we have elucidated the mechanism of activation of transient receptor potential ankyrin1 (TRPA1) channels; 1) Sulfhydration of cysteine residues in TRPA1 by H2Sn and the subsequent formation of a disulfide bond, induce conformational change to activate the channels, 2) H2Sn is produced by 3-mercaptopyruvate sulfurtransferase, 3) H2Sn react with cysteine and glutathione to produce Cys-SSH and GSSH, potential regulators of cellular redox state.
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