| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Collectin CL-K1 was a secreted protein and was known as an innate immune molecule involved in elimination of microbes, but CL-K1 was involved in development and growth, so we attempted to elucidate its role and mechanism. Regarding the developmental process, phenotypic abnormalities could be found in CL-K1 KO mice from the morphology from embryogenesis to birth after implantation and from blood biochemical data. Phenotypic analysis in adults revealed abnormal tissue in H-E staining of each tissue specimen, further found abnormality in bone formation by using X-ray and CT apparatus, and clarified renal function abnormality by hematological analysis and urinalysis.
By clarifying completely new functions other than biological defense of collectins, "dual function of biological defense proteins" could be proved in animal models.
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