Elucidation of the mechanisms of organ size determination
Project/Area Number |
26460358
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 臓器サイズ / 胚盤胞補完法 / 異種動物 / 異種胚盤胞補完法 / 異種キメラ / 臓器サイズ制御 / Hippo pathway |
Outline of Final Research Achievements |
In order to understand the mechanisms of determination of the size of body or the organ, - specifically, whether that is controlled by intrinsic or extrinsic cues, we performed interspecies blastocyst complementation. As a result, the size of mouse pancreas generated in rat was rat size (about ten times larger than mouse pancreas). This result indicate that the extrinsic signal as well as intrinsic signal is important for the organ size determination.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Interspecies organogenesis generates autologous functional islets.2017
Author(s)
Yamaguchi T, Sato H, Kato-Itoh M, Goto T, Hara H, Sanbo M, Mizuno N, Kobayashi T, Yanagida A, Umino A, Ota Y, Hamanaka S, Masaki H, Rashid ST, Hirabayashi M, Nakauchi H.
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Journal Title
Nature.
Volume: 542(7640)
Issue: 7640
Pages: 191-196
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos.2016
Author(s)
Masaki H, Kato-Itoh M, Takahashi Y, Umino A, Sato H, Ito K, Yanagida A, Nishimura T, Yamaguchi T, Hirabayashi M, Era T, Loh KM, Wu SM, Weissman IL, Nakauchi H.
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Journal Title
Cell Stem Cell.
Volume: 19(5)
Issue: 5
Pages: 587-592
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Practical selection methods for rat and mouse round spermatids without DNA staining by flow cytometric cell sorting2016
Author(s)
Hayama T, Yamaguchi T, Kato-Itoh M, Ishii Y, Mizuno N, Umino A, Sato H, Sanbo M, Hamanaka S, Masaki H, Hirabayashi M, Nakauchi H.
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Journal Title
Molecular Reproduction and Development
Volume: Epub ahead of print
Issue: 6
Pages: 488-96
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Matrix Metalloproteinase-14 Mediates Formation of Bile Ducts and Hepatic Maturation of Fetal Hepatic Progenitor Cells.2016
Author(s)
Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Kawai-Kitahata F, Nitta S, Nakata T, Okamoto R, Itsui Y, Nakagawa M, Azuma S, Asahina Y, Yamaguchi T, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.
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Journal Title
Biochem Biophys Res Commun
Volume: 469
Issue: 4
Pages: 1062-1068
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy.2015
Author(s)
Ando M, Nishimura T, Yamazaki S, Yamaguchi T, Kawana-Tachikawa A, Hayama T, Nakauchi Y, Ando J, Ota Y, Takahashi S, Nishimura K, Ohtaka M, Nakanishi M, Miles JJ, Burrows SR, Brenner MK, Nakauchi H.
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Journal Title
Stem Cell Reports.
Volume: 5(4)
Issue: 4
Pages: 597-608
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Interspecific in vitro assay for the chimera-forming ability of human pluripotent stem cells.2015
Author(s)
Masaki H, Kato-Itoh M, Umino A, Sato H, Hamanaka S, Kobayashi T, Yamaguchi T, Nishimura K, Ohtaka M, Nakanishi M, Nakauchi H.
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Journal Title
Development.
Volume: 142(18)
Pages: 3222-30
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner.2015
Author(s)
agida A, Chikada H, Ito K, Umino A, Kato-Itoh M, Yamazaki Y, Sato H, Kobayashi T, Yamaguchi T, Nakayama KI, Nakauchi H, Kamiya A.
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Journal Title
Dev Biol.
Volume: 407(2)
Issue: 2
Pages: 331-43
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Generation of Functional Oocytes by Xeno-Ectopic Transplantation of Primordial Germ Cells2014
Author(s)
Hayama T, Yamaguchi T, Kato-Itoh M, Hamanaka S, Kawarai M, Sanbo M, Tamura C, Lee YS, Yanagida A, Murayama H, Mizuno N, Umino A, Sato H, Yamazaki S, Masaki H, Kobayashi T, Hirabayashi M, Nakauchi H
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Journal Title
Biol Reprod
Volume: 91(4) 89
Issue: 4
Pages: 1-9
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 動物個体内での膵臓の再生2015
Author(s)
山口智之
Organizer
第101回日本消化器病学会総会
Place of Presentation
仙台 国際センター (宮城県仙台市)
Year and Date
2015-04-24
Related Report
Invited
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[Book] 最新医学2014
Author(s)
山口智之、中内啓光
Total Pages
10
Publisher
最新医学社
Related Report
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