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Elucidation of the mechanisms of organ size determination

Research Project

Project/Area Number 26460358
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

Yamaguchi Tomoyuki  東京大学, 医科学研究所, 特任准教授 (80392158)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords臓器サイズ / 胚盤胞補完法 / 異種動物 / 異種胚盤胞補完法 / 異種キメラ / 臓器サイズ制御 / Hippo pathway
Outline of Final Research Achievements

In order to understand the mechanisms of determination of the size of body or the organ, - specifically, whether that is controlled by intrinsic or extrinsic cues, we performed interspecies blastocyst complementation. As a result, the size of mouse pancreas generated in rat was rat size (about ten times larger than mouse pancreas). This result indicate that the extrinsic signal as well as intrinsic signal is important for the organ size determination.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (25 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (11 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 11 results,  Acknowledgement Compliant: 3 results,  Open Access: 7 results) Presentation (7 results) (of which Invited: 3 results) Book (6 results)

  • [Int'l Joint Research] Stanford university(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Interspecies organogenesis generates autologous functional islets.2017

    • Author(s)
      Yamaguchi T, Sato H, Kato-Itoh M, Goto T, Hara H, Sanbo M, Mizuno N, Kobayashi T, Yanagida A, Umino A, Ota Y, Hamanaka S, Masaki H, Rashid ST, Hirabayashi M, Nakauchi H.
    • Journal Title

      Nature.

      Volume: 542(7640) Issue: 7640 Pages: 191-196

    • DOI

      10.1038/nature21070

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos.2016

    • Author(s)
      Masaki H, Kato-Itoh M, Takahashi Y, Umino A, Sato H, Ito K, Yanagida A, Nishimura T, Yamaguchi T, Hirabayashi M, Era T, Loh KM, Wu SM, Weissman IL, Nakauchi H.
    • Journal Title

      Cell Stem Cell.

      Volume: 19(5) Issue: 5 Pages: 587-592

    • DOI

      10.1016/j.stem.2016.10.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Practical selection methods for rat and mouse round spermatids without DNA staining by flow cytometric cell sorting2016

    • Author(s)
      Hayama T, Yamaguchi T, Kato-Itoh M, Ishii Y, Mizuno N, Umino A, Sato H, Sanbo M, Hamanaka S, Masaki H, Hirabayashi M, Nakauchi H.
    • Journal Title

      Molecular Reproduction and Development

      Volume: Epub ahead of print Issue: 6 Pages: 488-96

    • DOI

      10.1002/mrd.22644

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Matrix Metalloproteinase-14 Mediates Formation of Bile Ducts and Hepatic Maturation of Fetal Hepatic Progenitor Cells.2016

    • Author(s)
      Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Kawai-Kitahata F, Nitta S, Nakata T, Okamoto R, Itsui Y, Nakagawa M, Azuma S, Asahina Y, Yamaguchi T, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 469 Issue: 4 Pages: 1062-1068

    • DOI

      10.1016/j.bbrc.2015.12.105

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils.2015

    • Author(s)
      Lin HT, Masaki H, Yamaguchi T, Wada T, Yachie A, Nishimura K, Ohtaka M, Nakanishi M, Nakauchi H, Otsu M.
    • Journal Title

      Mol Ther Methods Clin Dev

      Volume: 2 Pages: 15046-15046

    • DOI

      10.1038/mtm.2015.46

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigation of bi-potent differentiation of hepatoblasts using inducible diphtheria toxin receptor- transgenic mice.2015

    • Author(s)
      Yanagida A, Mizuno N, Yamazaki Y, Kato-Itoh M, Umino A, Sato H, Ito K, Yamaguchi T, Nakauchi H, Kamiya A.
    • Journal Title

      Hepatol Res.

      Volume: Nov 19. Issue: 8 Pages: 816-828

    • DOI

      10.1111/hepr.12622

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy.2015

    • Author(s)
      Ando M, Nishimura T, Yamazaki S, Yamaguchi T, Kawana-Tachikawa A, Hayama T, Nakauchi Y, Ando J, Ota Y, Takahashi S, Nishimura K, Ohtaka M, Nakanishi M, Miles JJ, Burrows SR, Brenner MK, Nakauchi H.
    • Journal Title

      Stem Cell Reports.

      Volume: 5(4) Issue: 4 Pages: 597-608

    • DOI

      10.1016/j.stemcr.2015.07.011

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interspecific in vitro assay for the chimera-forming ability of human pluripotent stem cells.2015

    • Author(s)
      Masaki H, Kato-Itoh M, Umino A, Sato H, Hamanaka S, Kobayashi T, Yamaguchi T, Nishimura K, Ohtaka M, Nakanishi M, Nakauchi H.
    • Journal Title

      Development.

      Volume: 142(18) Pages: 3222-30

    • DOI

      10.1242/dev.124016

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner.2015

    • Author(s)
      agida A, Chikada H, Ito K, Umino A, Kato-Itoh M, Yamazaki Y, Sato H, Kobayashi T, Yamaguchi T, Nakayama KI, Nakauchi H, Kamiya A.
    • Journal Title

      Dev Biol.

      Volume: 407(2) Issue: 2 Pages: 331-43

    • DOI

      10.1016/j.ydbio.2015.07.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Successful reprogramming of epiblast stem cells by blocking nuclear localization of beta-catenin2015

    • Author(s)
      Murayama H, Masaki H, Sato H, Hayama T, Yamaguchi T, Nakauchi H
    • Journal Title

      Stem cell reports

      Volume: 4 Issue: 1 Pages: 103-13

    • DOI

      10.1016/j.stemcr.2014.12.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of Functional Oocytes by Xeno-Ectopic Transplantation of Primordial Germ Cells2014

    • Author(s)
      Hayama T, Yamaguchi T, Kato-Itoh M, Hamanaka S, Kawarai M, Sanbo M, Tamura C, Lee YS, Yanagida A, Murayama H, Mizuno N, Umino A, Sato H, Yamazaki S, Masaki H, Kobayashi T, Hirabayashi M, Nakauchi H
    • Journal Title

      Biol Reprod

      Volume: 91(4) 89 Issue: 4 Pages: 1-9

    • DOI

      10.1095/biolreprod.114.121640

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 異種動物個体内での膵臓再生と膵島移植2017

    • Author(s)
      山口智之
    • Organizer
      第44回膵・膵島移植研究会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] 異種環境内における多能性幹細胞の発生限界2017

    • Author(s)
      山口智之
    • Organizer
      第16回日本再生医療学会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 動物個体内での膵臓の再生2016

    • Author(s)
      山口智之
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 異種体内で作製した膵島の移植による長期血糖値制御2016

    • Author(s)
      山口智之
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場 (大阪府大阪市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 異種動物体内でのiPS細胞からの膵臓作製2015

    • Author(s)
      山口智之
    • Organizer
      第10回信州肝胆膵外科先端医療研究会
    • Place of Presentation
      ホテルブエナビスタ(長野県松本市)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 多能性幹細胞の異種環境における発生限界2015

    • Author(s)
      山口智之
    • Organizer
      BMB2015(第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 動物個体内での膵臓の再生2015

    • Author(s)
      山口智之
    • Organizer
      第101回日本消化器病学会総会
    • Place of Presentation
      仙台 国際センター (宮城県仙台市)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 組織工学ライブラリ2016

    • Author(s)
      山口智之
    • Total Pages
      250
    • Publisher
      コロナ社
    • Related Report
      2016 Annual Research Report
  • [Book] 臨床薬学テキストシリーズ2016

    • Author(s)
      山口智之
    • Total Pages
      283
    • Publisher
      中山書店
    • Related Report
      2016 Annual Research Report
  • [Book] Hyper Bio Assembler for 3D Cellular Systems.2015

    • Author(s)
      Iriguchi S, Yamaguchi T
    • Total Pages
      78
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Book] 三次元ティッシュエンジニアリング2015

    • Author(s)
      山口智之
    • Total Pages
      6
    • Publisher
      株式会社エヌ・ティー・エス
    • Related Report
      2014 Research-status Report
  • [Book] 最新医学2014

    • Author(s)
      山口智之、中内啓光
    • Total Pages
      10
    • Publisher
      最新医学社
    • Related Report
      2014 Research-status Report
  • [Book] 医学のあゆみ2014

    • Author(s)
      山口智之
    • Total Pages
      1
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-01-27  

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