Grant-in-Aid for Scientific Research (C)
Nucleoredoxin (NRX) is a Thioredoxin family protein. We searched for novel binding protein for NRX, and identified glycolysis enzyme PFK1 as a major one.To clarify the regulation of glycolytic pathway by NRX, we performed metabolome analyses with wild type and NRX-deficient MEF cells. We found that the metabolites produced downstream of PFK1, such as lactate, decreased, and the products of pentose phosphate pathway, which diverges at the upstream of PFK1, increased. Thus, these results strengthen the notion that NRX regulates the balance between glycolytic pathway and the pentose phosphate pathway through PFK1.
Journal of Hypertension
Biochemical and Biophysical Research Communications
J Cell Sci.
Biochem Biophys Res Commun
J Clin Invest
J Biol Chem
Attribution of KAKENHI