Roles of the histone variant H3.3 on the distal enhancer of differentiation specific gene.
Project/Area Number |
26460373
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | Yokohama City University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
TAMURA Tomohiko 横浜市立大学, 医学研究科, 教授 (50285144)
KUROTAKI Daisuke 横浜市立大学, 医学部, 講師 (10568455)
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Research Collaborator |
FUSHIMI Kentaro
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 細胞分化 / エピジェネティックス / 遺伝子発現 / 転写因子 / ヒストンバリアント / ヒストン修飾 / 転写制御 |
Outline of Final Research Achievements |
Gene expression during cell differentiation is regulated by the epigenetic mechanisms, including histone variants, as well as lineage specific transcription factors. Histone variant H3.3 is known to be deposited in transcribed genes and associated with possibly maintenance of transcriptional memory. However, the functions of H3.3 on the distal enhancer are still unclear. In this study, we analyzed the roles of H3.3 on the distal enhancer of differentiation specific gene. H3.3 was first molecule that was deposited on both the distal enhancer and the proximal promoter synchronously, suggesting that H3.3 promotes the cooperation between the distal enhancer and the proximal promoter.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Biallelic TBCD mutations cause early-onset neurodegenerative encephalopathy2017
Author(s)
Miyake N, Fukai R, Ohba C, ... Shiina M, Ogata K, Okuno-Yuguchi J, Fueki N, Ogiso Y, Suzumura H, Watabe Y, Imataka G, Leong HY, Fattal-Valevski A, Kramer U, Miyatake S, Kato M, Okamoto N, Sato Y, Mitsuhashi S, Nishino I, Kaneko N, Nishiyama A, Tamura T, Mizuguchi T, Nakashima M, Tanaka F, Saitsu H, Matsumoto N
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Journal Title
American Journal of Human Genetics
Volume: 99
Issue: 4
Pages: 950-961
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity.2016
Author(s)
Ban T., Sato G.R., Nishiyama A., Akiyama A., Takasuna M., Umehara M., Suzuki S., Ichino M., Matsunaga S., Kimura A., Kimura Y., Yanai H., Miyashita S., Kuromitsu J., Tsukahara K., Yoshimatsu K., Endo I., Yamamoto T., Hirano H., Ryo A., Taniguchi T., Tamura T.
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Journal Title
Immunity
Volume: 45
Issue: 2
Pages: 319-332
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.2015
Author(s)
H. Sasaki, D. Kurotaki, N. Osato, H. Sato, I. Sasaki, S. Koizumi, H. Wang, C. Kaneda, A. Nishiyama, T. Kaisho, H. Aburatani, H. C. Morse III, K. Ozato, T. Tamura.
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Journal Title
Blood
Volume: 125(2)
Issue: 2
Pages: 358-369
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils2014
Author(s)
Kurotaki D., Yamamoto M., Nishiyama A., Uno K., Ban T., Ichino M., Sasaki H., Matsunaga S., Yoshinari M., Ryo A., Nakazawa M., Ozato K., Tamura T.
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Journal Title
Nature Communications
Volume: 5
Issue: 1
Pages: 4978-4978
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] The transcription factor IRF8 is essential for basophil development2014
Author(s)
Sasaki H., Kurotaki D., Osato N., Sato H., Sasaki I., Wang H., Kaneda C., Nishiyama A., Kaisho T., Aburatani H., Morse H.C. III, Ozato K., Tamura T.
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪国際会議場(大阪府)
Year and Date
2014-10-31
Related Report
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[Presentation] 転写因子IRF8によるC/EBPαの機能阻害が単球-樹状細胞前駆細胞における好中球分化能の喪失をもたらす2014
Author(s)
西山 晃, 黒滝大翼, 山本道雄, 宇野和宏, 藩 龍馬, 市野素英, 佐々木悠, 松永智子, 吉成正裕, 梁 明秀, 中澤正年, Keiko Ozato, 田村智彦
Organizer
新学術領域「転写サイクル」班会議
Place of Presentation
慶山(山梨県)
Year and Date
2014-08-05
Related Report
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[Presentation] 転写因子IRF8は好塩基球分化に必要である2014
Author(s)
佐々木悠, 黒滝大翼, 大里直樹, 佐藤英明, 佐々木泉, 小泉真一, 金田智香, 西山 晃, 油谷浩幸, 改正恒康, Herbert C. Morse III, Keiko Ozato, 田村智彦
Organizer
新学術領域「転写サイクル」班会議
Place of Presentation
慶山(山梨県)
Year and Date
2014-08-05
Related Report
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