| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Polycomb-repressive complex-1 (PRC1) including Cbx2, Ring1b, Mel18, and Phc2 are a chromatin regulator that plays central roles in stem cell identities. Little is known about the mechanisms of how PRC1 is stably recruited to its target gene loci. Cbx2 has an amino acid sequence typical to a DNA-binding motif AT-hook, suggesting a key player for PRC1 recruitment. Using mouse genetic approach, we here show that Cbx2 AT-hook is responsible for not only stable recruitment of Ring1b to target genes but also PRC1-mediated gene repressions. Our findings would provide new insights into stem cell regulations.
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