| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Dysfunction of the ubiquitination occurs in many neurodegenerative diseases, and neurotransmitter release abnormalities are also involved in many neurological diseases. We tried to understand integratively the regulation of cell and individual function by protein degradation through ubiquitin ligase SCRAPPER which we previously identified. In this study, we found that the amounts of some kinds of proteins were significantly altered in the knockout mouse brain. Moreover, it has become clear that behaviors of several neurotransmitters have changed in the multiple areas of the knockout mouse brain. These alterations may have deep relationship with the roles of SCRAPPER in neural tissue such as neurotransmitter release control, neural plasticity, and fear / anxiety-like behavior.
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