Novel molecular mechanisms that regulate tumor invasion and metastasis by association of cancer cells with surrounding stroma cells
| Project/Area Number |
26460389
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞接着 / シグナル伝達 / がん転移 / がん |
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| Outline of Final Research Achievements |
I focused on the tumor invasion and metastasis that is a major course of cancer death, and constructed the model to reflect this pathological condition in vitro. Using this model, I conducted the genome-wide analysis by DNA microarray assay to identify the genes of which expression was significantly increased in target cancer cells. After this analysis, I could select one gene. The gene product (molecule) is reported to localize on the plasma membrane of cancer cells. I found that the molecule remarkably promoted cancer cell motility, and that tumor invasion and metastasis was highly observed in the mice in which the cancer cells overexpressing the molecule were implanted. Furthermore, the signal transduction mechanism to facilitate cancer cell motility by this molecule was revealed successfully.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Novel mutations in the gene for α-subunit of retinal cone cyclic nucleotide-gated channels in a Japanese patient with congenital achromatopsia.2016
Author(s)
Kuniyoshi K, Muraki-Oda S, Ueyama H, Toyoda F, Sakuramoto H, Ogita H, Irifune M, Yamamoto S, Nakao A, Tsunoda K, Iwata T, Ohji M, Shimomura Y.
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Journal Title
Jpn J Ophthalmol.
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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