| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
I focused on the tumor invasion and metastasis that is a major course of cancer death, and constructed the model to reflect this pathological condition in vitro. Using this model, I conducted the genome-wide analysis by DNA microarray assay to identify the genes of which expression was significantly increased in target cancer cells. After this analysis, I could select one gene. The gene product (molecule) is reported to localize on the plasma membrane of cancer cells. I found that the molecule remarkably promoted cancer cell motility, and that tumor invasion and metastasis was highly observed in the mice in which the cancer cells overexpressing the molecule were implanted. Furthermore, the signal transduction mechanism to facilitate cancer cell motility by this molecule was revealed successfully.
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