The new function of insulin in gut.

• Project/Area Number: 26460392
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kumamoto University
• Principal Investigator: Yoshizawa Tatsuya 熊本大学, 大学院生命科学研究部(医), 准教授 (40313530)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: インスリン / 糖代謝 / 腸管 / インスリン受容体

Outline of Final Research Achievements

Gut is the tissue that is important to glucose metabolism, but it is not clear about the insulin action to gut. Therefore applicants generated the gut-specific insulin acceptor knockout (IR gutCKO) mice and analyzed influence on glucose metabolism. The IR gutCKO mice showed impaired glucose tolerance in the glucose tolerance test. In addition, expressions of many genes concerned with immunoreaction were changed in the gut of the IR gutCKO mice, and intestinal flora was changed in the IR gutCKO mice. These results indicate that an enteric insulin signal modulate immune system and change intestinal flora, thereby controlling glucose metabolism. Furthermore, it was shown that gut was the organ, which is hard to cause high fat diet-induced insulin resistance.

Research Products

• [Int'l Joint Research] Columbia University(米国)