| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Gut is the tissue that is important to glucose metabolism, but it is not clear about the insulin action to gut. Therefore applicants generated the gut-specific insulin acceptor knockout (IR gutCKO) mice and analyzed influence on glucose metabolism. The IR gutCKO mice showed impaired glucose tolerance in the glucose tolerance test. In addition, expressions of many genes concerned with immunoreaction were changed in the gut of the IR gutCKO mice, and intestinal flora was changed in the IR gutCKO mice. These results indicate that an enteric insulin signal modulate immune system and change intestinal flora, thereby controlling glucose metabolism. Furthermore, it was shown that gut was the organ, which is hard to cause high fat diet-induced insulin resistance.
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