Mechanisms of increased glucose-stimulated insulin secretion during pregnancy
| Project/Area Number |
26460396
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
AOYAGI Kyota 杏林大学, 医学部, 講師 (50453527)
NAGAMATSU Shinya 杏林大学, 医学部, 教授 (80231489)
OKAMURA Tadashi 独立行政法人 国立国際医療センター, 研究所, 室長 (00333790)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | インスリン分泌 / 膵β細胞 / 妊娠糖尿病 / 糖尿病 / 妊娠 / 開口分泌 / 開口放出 |
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| Outline of Final Research Achievements |
In preparation for the metabolic demands of pregnancy, β cells in the maternal pancreatic islets increase both in number and in glucose-stimulated insulin secretion per cell. Mechanisms have been proposed for the increased β cell mass, but not for the increased glucose-stimulated insulin secretion. Here we show using knockout mice for P2X7-purinoreceptor and CDKAL1, a type 2 diabetes susceptibility gene that (i) ATP, acting in a paracrine/autocrine manner through P2X7 plays an essential role in the increased glucose-stimulated insulin secretion of pregnancy; (ii) the decreased expression of CDKAL1 is associated with reduced glucose-stimulated insulin secretion during pregnancy.
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Report
(5 results)
Research Products
(28 results)
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[Journal Article] In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains.2017
Author(s)
Krishnankutty, A., Kimura, T., Saito, T., Aoyagi, K., Asada, A., Takahashi, S., Ando, K., Ohara-Imaizumi, M., Ishiguro, K., Hisanaga, S.
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 8602-8602
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] VAMP7 regulates autophagy to maintain mitochondrial homeostasis and to control insulin secretion in pancreatic beta-cells.2016
Author(s)
Aoyagi K, Ohara-Imaizumi M, Itakura M, Torii S, Akimoto Y, Nishiwaki C, Nakamichi Y, Kishimoto T, Kawakami H, Harada A, Takahashi M, Nagamatsu S
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Journal Title
Diabetes
Volume: 65
Issue: 6
Pages: 1648-1659
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Role of active zone protein ELKS in insulin secretion from pancreatic β-cells.2017
Author(s)
Ohara-Imaizumi M. Hida, Y., Yoshida, M., Aoyagi, K., Ohkura, M., Sakimura, K., Nakai, J., Kakei, M., Nagamatsu, S., Ohtsuka, T.
Organizer
第11回Diabetes Leading-edge Conference
Related Report
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