Elucidation of mucosal repair mechanism mediated by interleukin 11 in inflammatory bowel disease
| Project/Area Number |
26460397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小島 裕子 順天堂大学, 医学(系)研究科(研究院), 助教 (60231312)
出口 裕 東邦大学, 医学部, 助教 (10287526)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | レポーターマウス / 大腸炎 / IL-11 / 大腸がん / IL-6サイトカインファミリー / 粘膜 / サイトカイン / 修復 / 大腸癌 / il-6サイトカインファミリー / 恒常性 / 腸炎 / 腸管 |
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| Outline of Final Research Achievements |
Interleukin (IL)-11 is a member of IL-6 family of cytokines that activates signal transducer and activator of transcription 3. Accumulating studies have shown that IL-11 is highly expressed in inflammatory bowl diseases and colorectal cancers in human and mice. However, it remains unclear whether IL-11 plays a crucial role in maintaining tissue homeostasis of the intestine. In this study, using dextran sodium sulfate (DSS)-induced colitis in mice as a model, we found that IL-11 was produced by non-bone marrow-derived cells that were localized in injured intestinal tissues. Moreover, IL-11 primarily acted on intestinal epithelial cells and protected injury of intestinal epithelial cells, thereby attenuating DSS-induced colitis. These findings indicate that IL-11 plays a crucial for maintaining intestinal homeostasis.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum2017
Author(s)
Piao X, Yamazaki S, Komazawa-Sakon S, Miyake S, Nakabayashi O, Kurosawa T, Mikami T, Tanaka M, Van Rooijen N, Ohmuraya M, Oikawa A, Kojima Y, Kakuta S, Uchiyama Y, Tanaka M, Nakano H.
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Journal Title
Hepatology
Volume: 65
Pages: 237-252
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome2016
Author(s)
Sakata K, Araki K, Nakano H, Nishina T, Komazawa-Sakon S, Murai S, Lee GE, Hashimoto D, Suzuki C, Uchiyama Y, Notohara K, Gukovskaya AS, Gukovsky I, Yamamura KI, Baba H, Ohmuraya M.
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Journal Title
Sci Rep
Volume: 6
Pages: 37200-37200
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Development of Accelerated Coronary Atherosclerosis Model Using Low Density Lipoprotein Receptor Knock-Out Swine with Balloon Injury.2016
Author(s)
Ogita M, Miyauchi K, Onishi A, Tsuboi S, Wada H, Konishi H, Naito R, Dohi T, Kasai T, Kojima Y, Schwartz RS, Daida H.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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