The investigation of the molecular mechanisms in COMT-deficiency-induced health problems
Project/Area Number |
26460403
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
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Research Institution | Kanazawa Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
金崎 めぐみ 金沢医科大学, 医学部, 助教 (50599355)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | COMT / メタボリックシンドローム / 妊娠高血圧腎症 / エストロゲン代謝 / アンジオテンシン / PPAR-g / 2-methoxyestradiol / metabolic syndrome / insulin / 生活習慣病 / 耐糖能異常 / 高血圧 |
Outline of Final Research Achievements |
This applicant reported the first genetic model of preeclampsia by showing that catechol-o-methytransferase (COMT) deficient mice, displaying defects in catechol metabolism, exhibited preeclampsia phenotype during gestation. Preeclamspia and metabolic syndrome share some of clinical manifestation, therefore this applicant hypothesized that COMT deficiency could be relevant for the pathogenesis of both preeclampsia and metabolic syndrome. Indeed some of genetic analysis in the past supported this applicant's hypothesis. By completion of this application, this applicant revealed that at least two major clinical symptom of metabolic syndrome, hypertension and glucose intolerance, could be explained by COMT deficiency. Therefore COMT deficiency could be relevant pathomechanism in both preeclampsia and metabolic syndrome.
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Report
(4 results)
Research Products
(87 results)
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[Journal Article] Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: A multicenter, randomized clinical trial2015
Author(s)
1.Kato S, Maruyama S, Makino H, Wada J, Ogawa D, Uzu T, Araki H, Koya D, Kanasaki K, Oiso Y, Goto M, Nishiyama A, Kobori H, Imai E, Ando M, and Matsuo S
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Journal Title
Clin Experim Nephrol
Volume: 19
Issue: 6
Pages: 1098-1106
DOI
Related Report
Peer Reviewed
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[Journal Article] Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial2015
Author(s)
Sawako Kato, Shoichi Maruyama, Hirofumi Makino, Jun Wada, Daisuke Ogawa, Takashi Uzu, Hisazumi Araki, Daisuke Koya, Keizo Kanasaki, Yutaka Oiso, Motomitsu Goto, Akira Nishiyama, Hiroyuki Kobori, Enyu Imai, Masahiko Ando, Seiichi Matsuo
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Journal Title
Clin Exp Nephrol.
Volume: 印刷中
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Combating Kidney Fibrosis2014
Author(s)
Keizo Kanasaki, Akito Maeshima, Gangadhar Taduri, Ignacio Revuela.
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Journal Title
Biomed Res Int
Volume: 該当なし
Pages: 1-2
DOI
Related Report
Open Access / Acknowledgement Compliant
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[Journal Article] Cancer Biology in Diabetes2014
Author(s)
Sen Shi, Yanzheng He, Daisuke Koya, Keizo Kanasaki
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Journal Title
Journal of Diabetes Investigation
Volume: 5
Issue: 3
Pages: 251-264
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 壊死性筋膜炎を伴った糖尿病性腎症の1症例2015
Author(s)
金崎 啓造, 渡辺 愛, 中川 淳, 北田 宗弘, 永井 貴子, 伊藤 弘樹, 津田 真一, 小西 一典, 西澤 誠, 古家 大祐
Organizer
日本腎臓学会西部学術大会
Place of Presentation
金沢歌劇座 (石川県金沢市)
Year and Date
2015-10-23
Related Report
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[Presentation] COMT不全と糖代謝異常2015
Author(s)
金崎啓造
Organizer
日本妊娠高血圧学会
Place of Presentation
北海道大学 学術交流会館 (北海道、札幌市)
Year and Date
2015-09-11 – 2015-09-12
Related Report
Invited
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