| Project/Area Number |
26460410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
星 信彦 神戸大学, 農学研究科, 教授 (10209223)
三木 崇範 香川大学, 医学部, 教授 (30274294)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 性分化 / 性分化疾患 / エピジェネティクス / SRY / DMRT1 / 真性半陰陽 / dmrt1 / AMH / 性腺 / 転写調節 / エピジェネティック / Sry / 左右差 / 内部標準遺伝子 / Sox9 |
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| Outline of Final Research Achievements |
We examined the relationship between regulation mechanisms of gonadal sex differentiation and disorders of sex development (DSD). In the DSD line mice (YPOS), inappropriate spatiotemporal expression of sex determine gene Sry and sex differentiation related genes in the developing gonad cause different phenotype from the same genetic background. We found new regulatory mechanism about sex differentiation related gene dmrt1 using non-coding region of dmrt1 gene. The epigenetic status of this region was non-methylated both in the testis and ovary in adult mice. Furthermore, it became clear that, there were asymmetries in the expression patterns of dmrt1 and differentiation process of Sertoli cells in the developing chick gonad.
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