Progesteron Receptor Expression in Pancreatic Neuroendocrine Tumor

• Project/Area Number: 26460413
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Tohoku University
• Principal Investigator: KASAJIMA ATSUKO 東北大学, 医学系研究科, 大学院非常勤講師 (50623005)
• Co-Investigator(Renkei-kenkyūsha): SASANO Hironobu 東北大学, 医学系研究科, 教授 (50187142) ; NAKAMURA Yasuhiro 東北医科薬科大学, 医学部, 教授 (80396499) ; MIKI Yasuhiro 東北大学, 災害科学国際研究所, 講師 (50451521)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経内分泌腫瘍 / 内分泌腫瘍 / Neuroendocrine tumor / Progesteron receptor / Cell cycle

Outline of Final Research Achievements

Progesteron receptor: PR is frequently expressed in pancreatic neuroendocrine tumor: PNET and is related to a longer prognosis of the patients. However, its mechanism is not clarified. Expression of PR subtype A (PRA) was negatively associated with multiple cell cycle regulators and with proliferative activities in PNET tissues. In addition, expression induced decrease expression of multiple cell cycle related gene (CCNA2, CCNB1, CDK1, CDK2) and inhibited cell cycle in a PNET cell line (QGP1).
These results suggested that PRA is closely associated with inhibition of cell cycle and can be a target molecule in treatment for patients with PNET.

Research Products

• [Journal Article] The Risk Factors for Metastasis in Non-Ampullary Duodenal Neuroendocrine Tumors Measuring 20 mm or Less in Diameter (2017)
  • Author(s): Hatta, W. Koike, T. Iijima, K. Asanuma, K. Asano, N. Musha, H. Inomata, Y. Sano, T. Endo, H. Ikehata, A. Horii, T. Ohyauchi, M. Yokosawa, S. Kasajima, A. Fujishima, F. Sasano, H. Nakaya, N. Nakamura, T. Shimosegawa, T.
  • Journal Title: Digestion Volume: 95 Issue: 3 Pages: 201-9
  • DOI: 10.1159/000459619
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] SOX2 and Rb1 in esophageal small-cell carcinoma: their possible involvement in pathogenesis (2017)
  • Author(s): Ishida H, Kasajima A, Kamei T, Miura T, Oka N, Yazdani S, Ozawa Y, Fujishima F, Sakurada A, Nakamura Y, Tanaka Y, Kurosumi M, Ishikawa Y, Okada Y, Ohuchi N, Sasano H
  • Journal Title: Mod Pathol Volume: 30 Issue: 5 Pages: 660-671
  • DOI: 10.1038/modpathol.2016.222
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer. (2016)
  • Author(s): Mori N, Mugikura S, Takasawa C, Miyashita M, Shimauchi A, Ota H, Ishida T, Kasajima A, Takase K, Kodama T, Takahashi S.
  • Journal Title: European Radiology Volume: 26(2) Issue: 2 Pages: 331-9
  • DOI: 10.1007/s00330-015-3888-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A case of pulmonary adenocarcinoma harboring osteoclast-like giant cells: Its evaluation by immunohistochemical and genetic analyses. (2016)
  • Author(s): Saito R, Fujishima F, Nakamura Y, Hoshikawa Y, Tominaga J, Taniuchi S, Kasajima A, Watanabe M, Okada Y, Sasano H.
  • Journal Title: Pathology International Volume: in press Issue: 4 Pages: 224-9
  • DOI: 10.1111/pin.12395
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Advances in the diagnosis and treatment of pancreatic neuroendocrine neoplasms in Japan (2016)
  • Author(s): Ito, T. Hijioka, S. Masui, T. Kasajima, A. Nakamoto, Y. Kobayashi, N. Komoto, I. Hijioka, M. Lee, L. Igarashi, H. Jensen, R. T. Imamura, M.
  • Journal Title: J Gastroenterol Volume: 52 Issue: 1 Pages: 9-18
  • DOI: 10.1007/s00535-016-1250-9
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A Calcitonin Non-producing Neuroendocrine Tumor of the Thyroid Gland. (2016)
  • Author(s): Kasajima A, Cameselle-Teijeiro J, Loidi L, Takahashi Y, Nakashima N, Sato S, Fujishima F, Watanabe M, Nakazawa T, Naganuma H, Kondo T, Kato R, Sasano H.
  • Journal Title: Endocrine Pathology Volume: in press
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects. (2016)
  • Author(s): Kuroda N, Karashima T, Inoue K, Kasajima A, Ohe C, Kawakami F, Mikami S, Matsuura K, Moriyama M, Nagashima Y, Petersson F, Lopez JI, Cohen RJ, Michal M, Hes O.
  • Journal Title: Polish Journal Pathology Volume: 66(1) Pages: 3-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Precise Preoperative Localization of Prostate Cancer Employing 12-Core Needle Biopsy with a Tissue-Marking Method for Effective Surgical Strategy (2015)
  • Author(s): Sato S, Watanabe M, Taniuchi S, Kasajima A, Mitsuzuka K, Nakamura Y, Fujishima F, Arai Y, Sasano H.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 236 Issue: 1 Pages: 55-61
  • DOI: 10.1620/tjem.236.55
  • NAID: 130005069563
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Progesterone Receptor Isoforms A and B in Pancreatic Neuroendocrine Tumor (2015)
  • Author(s): Yazdani, S. Kasajima, A. Ogata, H. Felizola, S. J. Nakamura, Y. Onodera, Y. Motoi, F. Unno, M. Watanabe, M. Sasano, H.
  • Journal Title: Neuroendocrinology Volume: in press Issue: 4 Pages: 309-320
  • DOI: 10.1159/000381455
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pathology diagnosis of pancreatic neuroendocrine tumors. (2015)
  • Author(s): Kasajima, A. Yazdani, S. Sasano, H.
  • Journal Title: Journal of hepato-biliary-pancreatic sciences Volume: in press Issue: 8 Pages: 586-593
  • DOI: 10.1002/jhbp.208
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] G-cell hyperplasia of the stomach induces ECL-cell proliferation in the pyloric glands in a paracrinal manner (2015)
  • Author(s): Kasajima, A. Fujishima, F. Morikawa, T. Kawasaki, S. Konosu-Fukaya, S. Shibahara, Y. Nakamura, T. Yoshikawa, T. Iijima, K. Koike, T. Watanabe, M. Shibata, C. Sasano, H.
  • Journal Title: Pathology International Volume: 65 Issue: 5 Pages: 259-63
  • DOI: 10.1111/pin.12276
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Angiogenesis and vascular maturation in neuroendocrine tumors (2014)
  • Author(s): Yazdani, S. Kasajima, A. Tamaki, K. Nakamura, Y. Fujishima, F. Ohtsuka, H. Motoi, F. Unno, M. Watanabe, M. Sato, Y. Sasano, H.
  • Journal Title: Human Pathology Volume: 45 Issue: 4 Pages: 866-74
  • DOI: 10.1016/j.humpath.2013.09.024
  • Peer Reviewed / Open Access
• [Journal Article] Oncocytic adrenocortical neoplasm arising from adrenal rest in the broad ligament of the uterus (2014)
  • Author(s): Kasajima, A. Nakamura, Y. Adachi, Y. Takahashi, Y. Fujishima, F. Chiba, Y. Uehara, S. Watanabe, M. Sasano, H.
  • Journal Title: Pathology International Volume: 4 Issue: 4 Pages: 183-8
  • DOI: 10.1111/pin.12154
  • Peer Reviewed / Open Access
• [Presentation] Prognostic and anti-tumoral significance of inflammatory reaction in broncho-pulmonary neuroendocrine neoplasms (2017)
  • Author(s): Atsuko Kasajima, Ayaka Iwata, Naomi Oka, Hirotaka Ishida, Akira Sakurada, Toru Kameya, Yuichi Ishikawa, Katja Steiger, Bjoern Konukiewitz, Guenter Kloeppel, Yoshinori Okada, Hironobu Sasano, Wilko Weichert
  • Organizer: 101. Jahrestagung der Deutschen Geselschaft der Pathologie
  • Place of Presentation: Erlamgen, Germany
  • Year and Date: 2017-07-22
• [Presentation] Multiple pancreatic neuroendocrine neoplasms; What pathologists should consider? (2017)
  • Author(s): Atsuko Kasajima, Satoko Sato, Tomoyoshi Tachibana, Samaneh Yazdani, Bjoern Konukiewitz, Wilko Weichert, Guenter Kloeppel, Hironobu Sasano
  • Organizer: 10th Asia Pacific IAP Congress 2017
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2017-04-24
  • Int'l Joint Research / Invited
• [Presentation] Prognosis and Incidence in Pancreatic and Gastrointestinal Neuroendocrine Neoplasms with emphasis on “NET G3”: An analysis of 198 cases from Japan (2017)
  • Author(s): Atsuko Kasajima, Tomoyoshi Tachibana, Hirotaka Ishida, Samaneh Yazdani, Bjoern Konukiewitz, Guenter Kloeppel, Wilko Weichert, Hironobu Sasano
  • Organizer: 14th European Neuroendocrine Tumor Society
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2017-03-08
  • Int'l Joint Research
• [Presentation] Atsuko Kasajima, Naomi Oka, Hirotaka Ishida, Akira Sakurada, Toru Kameya, Bjoern Konukiewitz, Guenter Kloeppel, Wilko Weichert, Yuichi Ishikawa, Yoshinori Okada, Hironobu Sasano (2017)
  • Author(s): Classification of lung neuroendocrine neoplasms (Lung-NENs) according to WHO 2010 for gastroenteropancreatic NENs (GEP-NENs) has prognostic relevance and includes Lung-NETs G3.
  • Organizer: 14th European Neuroendocrine Tumor Society
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2017-03-08
  • Int'l Joint Research
• [Presentation] 食道および肺小細胞癌に共通する免疫組織学的な腺上皮分化 (2016)
  • Author(s): 石田 裕嵩, 笠島 敦子, 亀井 尚, 岡 直美, サマネ・ヤズダニ, 藤島 史喜, 桜田 晃, 中村 保宏, 田中 洋一, 黒住 昌史, 石川 雄一, 岡田 克典, 大内 憲明, 笹野 公伸
  • Organizer: 第4回日本神経内分泌腫瘍研究会学術集会
  • Place of Presentation: 東京大学伊藤国際学術研究センター（東京都文京区）
  • Year and Date: 2016-09-24
• [Presentation] 免疫組織化学によるSomatostatin receptor (SSTR) の施設・観察者間一致性に関する検討 (2016)
  • Author(s): 伊藤渉, 笠島敦子, 橘知睦, Samaneh Yazdani, Mauro Papotti, Marco Volante, 笹野公伸
  • Organizer: 第4回日本神経内分泌腫瘍研究会学術集会
  • Place of Presentation: 東京大学伊藤国際学術研究センター（東京都文京区）
  • Year and Date: 2016-09-24
• [Presentation] 岡 直美，笠島 敦子, 石田 裕嵩, サマネ ヤズダニ, 桜田 晃, 櫻田 潤子, 鈴木 博義, 石川 雄一, 岡田 克典, 笹野 公伸 (2016)
  • Author(s): 肺神経内分泌腫瘍197症例の臨床病理組織学的検討
  • Organizer: 第4回日本神経内分泌腫瘍研究会学術集会
  • Place of Presentation: 東京大学伊藤国際学術研究センター（東京都文京区）
  • Year and Date: 2016-09-24
• [Presentation] Progesterone Receptor Isoform A Inhibits Cyclin B1 Expression in Pancreatic Neuroendocrine Tumor (2016)
  • Author(s): Samaneh Yazdani, Atsuko Kasajima, Hironobu Sasano
  • Organizer: 第4回日本神経内分泌腫瘍研究会学術集会
  • Place of Presentation: 東京大学伊藤国際学術研究センター（東京都文京区）
  • Year and Date: 2016-09-24
• [Presentation] 膵消化管神経内分泌腫瘍 Gastroenteropancreatic Neuroendocrine Tumor : GEP-NET 病理診断 up-to-date (2015)
  • Author(s): 笠島敦子
  • Organizer: 日本消化器病学会東北支部会 第17回教育講演会
  • Place of Presentation: ホテルメトロポリタン盛岡、岩手
  • Year and Date: 2015-11-22
  • Invited
• [Presentation] Profiling of cell cycle pathway genes in pancreatic neuroendocrine tumor cell line after treatment with progesterone. (2015)
  • Author(s): Yazdani S, Kasajima A, Sasano H.
  • Organizer: 3rd Congress on Steroid Research
  • Place of Presentation: Hyatt Regency McCormick Place, Chicago, USA
  • Year and Date: 2015-11-15
  • Int'l Joint Research
• [Presentation] 膵EUS-FNAにおける 膵神経内分泌腫瘍と形態の類似する膵病変の 免疫組織化学を用いた鑑別診断 (2015)
  • Author(s): 笠島敦子、笹野公伸
  • Organizer: 第56回日本組織細胞化学学会学術総会
  • Place of Presentation: 関西医科大学枚方病院、大阪
  • Year and Date: 2015-10-03
• [Presentation] EUS-FNAにおける膵NETの病理診断 (2015)
  • Author(s): 笠島敦子、安達友津、小泉輝樹、三浦弘守、 菅野敦、藤島史喜、笹野公伸
  • Organizer: 第三回日本神経内分泌腫瘍研究会学術集会
  • Place of Presentation: 仙台市民会館、仙台、宮城
  • Year and Date: 2015-09-12
• [Presentation] Progesterone-induced cell cycle gene expression profiling by PCR array in pancreatic neuroendocrine tumor cell line. (2015)
  • Author(s): Yazdani S, Kasajima A, Sasano H.
  • Organizer: 第三回日本神経内分泌腫瘍研究会学術集会
  • Place of Presentation: 仙台市民会館、仙台、宮城
  • Year and Date: 2015-09-12
• [Presentation] Interesting Case Presentations: A case of multiple gastrointestinal endocrine and non-endocrine neoplasms (2015)
  • Author(s): Atsuko Kasajima, Hironobu Sasano
  • Organizer: Asia Pacific international academy of Pathology
  • Place of Presentation: Brisbane Convention & Exhibition Centre, Brisbane, Queensland, Australia.
  • Year and Date: 2015-06-04
  • Int'l Joint Research / Invited
• [Presentation] ファーター乳頭部領域腫瘍 - 概念と診断 -非外分泌腫瘍 神経内分泌腫瘍を中心に (2015)
  • Author(s): 笠島敦子、笹野公伸
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場、愛知
  • Year and Date: 2015-04-30
• [Presentation] Progesterone Receptor Isoforms A and B in Pancreatic Neuroendocrine Tumor (2015)
  • Author(s): Yazdani S, Kasajima A, Felizola S JA, Onodera Y, Nakamura Y, Sasano H.
  • Organizer: ENDO2015: The endocrine Society annual meeting
  • Place of Presentation: San Diego, California
  • Year and Date: 2015-04-01
  • Int'l Joint Research
• [Presentation] 神経内分泌腫瘍の病理診断：現状と課題 S1-4. 神経内分泌腫瘍におけるKi67 labeling indexに関する最近の話題Ki67の自動計測の実用化にむけた課題. (2014)
  • Author(s): 笠島敦子, 佐藤聡子, 山崎有人, 笹野公伸.
  • Organizer: 第18回日本内分泌病理学会学術集会
  • Place of Presentation: 東京, 都道府県会館
  • Year and Date: 2014-11-01
• [Presentation] A case of hypergastrinemia. (2014)
  • Author(s): Kasajima A, Sasano H.
  • Organizer: The 5th Taiwan-Japanese Conjoint Slide Conference of the International Academy of Pathology.
  • Place of Presentation: Taipei, Howard Civil Service International House
  • Year and Date: 2014-10-26
• [Presentation] Pancreatic neuroendocrine tumor, oncocytic variant. (2014)
  • Author(s): Kasajima A, Sasano H.
  • Organizer: International academy of pathology 2014
  • Place of Presentation: Bangkok, Bangkok Convention Centre at Centralworld
  • Year and Date: 2014-10-05 – 2014-10-10
• [Presentation] EUS-FNA検体で病理診断を行う際の注意事項と最近のトピックス. (2014)
  • Author(s): 笠島敦子, 笹野公伸
  • Organizer: 第2回日本神経内分泌腫瘍研究会学術集会.
  • Place of Presentation: 東京, 東京大学伊藤国際学術研究センター
  • Year and Date: 2014-09-20
• [Presentation] EUS-FNAにおける膵腫瘍の細胞診断 solid-pseudopapillary neoplasmとneuroendocrine neoplasmの鑑別について (2014)
  • Author(s): 安達友津, 三浦弘守, 笠島敦子, 谷内真司, 藤島史喜, 渡辺みか, 笹野公伸
  • Organizer: 第51回日本臨床細胞学会東北支部連合会学術集会.
  • Place of Presentation: 秋田, 秋田県総合保健センター
  • Year and Date: 2014-07-05
• [Presentation] The current Status of Pancreatic Neuroendocrine Tumors. Histopathological features and WHO classification of PNET. (2014)
  • Author(s): Kasajima A, Sasano H
  • Organizer: The 87th Annual Meeting of the Japan Endocrine Society
  • Place of Presentation: Fukuoka, Fukuoka Convention Centre
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 内分泌病理から臨床へのフィードバック. 膵消化管神経内分泌腫瘍のWHO分類. (2014)
  • Author(s): 笠島敦子, 笹野公伸
  • Organizer: 第87回日本内分泌学会学術総会
  • Place of Presentation: 福岡, 福岡国際会議場
  • Year and Date: 2014-04-24 – 2014-04-26
• [Book] 消化管NET 第1部-第3部 (2017)
  • Author(s): 笠島 敦子 笹野 公伸
  • Total Pages: 20
  • Publisher: 腫瘍病理鑑別疾患アトラス 内分泌
• [Book] WHO2010分類の妥当性と今後の病理診断の展望 (2016)
  • Author(s): 笠島 敦子 笹野 公伸
  • Total Pages: 4
  • Publisher: 胆と膵
• [Book] 腫瘍病理鑑別診断アトラス 胆道癌・膵癌 (2015)
  • Author(s): 笠島敦子, 笹野公伸
  • Total Pages: 6
  • Publisher: 文光堂