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Progesteron Receptor Expression in Pancreatic Neuroendocrine Tumor

Research Project

Project/Area Number 26460413
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionTohoku University

Principal Investigator

KASAJIMA ATSUKO  東北大学, 医学系研究科, 大学院非常勤講師 (50623005)

Co-Investigator(Renkei-kenkyūsha) SASANO Hironobu  東北大学, 医学系研究科, 教授 (50187142)
NAKAMURA Yasuhiro  東北医科薬科大学, 医学部, 教授 (80396499)
MIKI Yasuhiro  東北大学, 災害科学国際研究所, 講師 (50451521)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経内分泌腫瘍 / 内分泌腫瘍 / Neuroendocrine tumor / Progesteron receptor / Cell cycle
Outline of Final Research Achievements

Progesteron receptor: PR is frequently expressed in pancreatic neuroendocrine tumor: PNET and is related to a longer prognosis of the patients. However, its mechanism is not clarified. Expression of PR subtype A (PRA) was negatively associated with multiple cell cycle regulators and with proliferative activities in PNET tissues. In addition, expression induced decrease expression of multiple cell cycle related gene (CCNA2, CCNB1, CDK1, CDK2) and inhibited cell cycle in a PNET cell line (QGP1).
These results suggested that PRA is closely associated with inhibition of cell cycle and can be a target molecule in treatment for patients with PNET.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (39 results)

All 2017 2016 2015 2014

All Journal Article (13 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 13 results,  Open Access: 11 results,  Acknowledgement Compliant: 6 results) Presentation (23 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results) Book (3 results)

  • [Journal Article] The Risk Factors for Metastasis in Non-Ampullary Duodenal Neuroendocrine Tumors Measuring 20 mm or Less in Diameter2017

    • Author(s)
      Hatta, W. Koike, T. Iijima, K. Asanuma, K. Asano, N. Musha, H. Inomata, Y. Sano, T. Endo, H. Ikehata, A. Horii, T. Ohyauchi, M. Yokosawa, S. Kasajima, A. Fujishima, F. Sasano, H. Nakaya, N. Nakamura, T. Shimosegawa, T.
    • Journal Title

      Digestion

      Volume: 95 Issue: 3 Pages: 201-9

    • DOI

      10.1159/000459619

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] SOX2 and Rb1 in esophageal small-cell carcinoma: their possible involvement in pathogenesis2017

    • Author(s)
      Ishida H, Kasajima A, Kamei T, Miura T, Oka N, Yazdani S, Ozawa Y, Fujishima F, Sakurada A, Nakamura Y, Tanaka Y, Kurosumi M, Ishikawa Y, Okada Y, Ohuchi N, Sasano H
    • Journal Title

      Mod Pathol

      Volume: 30 Issue: 5 Pages: 660-671

    • DOI

      10.1038/modpathol.2016.222

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer.2016

    • Author(s)
      Mori N, Mugikura S, Takasawa C, Miyashita M, Shimauchi A, Ota H, Ishida T, Kasajima A, Takase K, Kodama T, Takahashi S.
    • Journal Title

      European Radiology

      Volume: 26(2) Issue: 2 Pages: 331-9

    • DOI

      10.1007/s00330-015-3888-8

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A case of pulmonary adenocarcinoma harboring osteoclast-like giant cells: Its evaluation by immunohistochemical and genetic analyses.2016

    • Author(s)
      Saito R, Fujishima F, Nakamura Y, Hoshikawa Y, Tominaga J, Taniuchi S, Kasajima A, Watanabe M, Okada Y, Sasano H.
    • Journal Title

      Pathology International

      Volume: in press Issue: 4 Pages: 224-9

    • DOI

      10.1111/pin.12395

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Advances in the diagnosis and treatment of pancreatic neuroendocrine neoplasms in Japan2016

    • Author(s)
      Ito, T. Hijioka, S. Masui, T. Kasajima, A. Nakamoto, Y. Kobayashi, N. Komoto, I. Hijioka, M. Lee, L. Igarashi, H. Jensen, R. T. Imamura, M.
    • Journal Title

      J Gastroenterol

      Volume: 52 Issue: 1 Pages: 9-18

    • DOI

      10.1007/s00535-016-1250-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A Calcitonin Non-producing Neuroendocrine Tumor of the Thyroid Gland.2016

    • Author(s)
      Kasajima A, Cameselle-Teijeiro J, Loidi L, Takahashi Y, Nakashima N, Sato S, Fujishima F, Watanabe M, Nakazawa T, Naganuma H, Kondo T, Kato R, Sasano H.
    • Journal Title

      Endocrine Pathology

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects.2016

    • Author(s)
      Kuroda N, Karashima T, Inoue K, Kasajima A, Ohe C, Kawakami F, Mikami S, Matsuura K, Moriyama M, Nagashima Y, Petersson F, Lopez JI, Cohen RJ, Michal M, Hes O.
    • Journal Title

      Polish Journal Pathology

      Volume: 66(1) Pages: 3-8

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Precise Preoperative Localization of Prostate Cancer Employing 12-Core Needle Biopsy with a Tissue-Marking Method for Effective Surgical Strategy2015

    • Author(s)
      Sato S, Watanabe M, Taniuchi S, Kasajima A, Mitsuzuka K, Nakamura Y, Fujishima F, Arai Y, Sasano H.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 236 Issue: 1 Pages: 55-61

    • DOI

      10.1620/tjem.236.55

    • NAID

      130005069563

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progesterone Receptor Isoforms A and B in Pancreatic Neuroendocrine Tumor2015

    • Author(s)
      Yazdani, S. Kasajima, A. Ogata, H. Felizola, S. J. Nakamura, Y. Onodera, Y. Motoi, F. Unno, M. Watanabe, M. Sasano, H.
    • Journal Title

      Neuroendocrinology

      Volume: in press Issue: 4 Pages: 309-320

    • DOI

      10.1159/000381455

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pathology diagnosis of pancreatic neuroendocrine tumors.2015

    • Author(s)
      Kasajima, A. Yazdani, S. Sasano, H.
    • Journal Title

      Journal of hepato-biliary-pancreatic sciences

      Volume: in press Issue: 8 Pages: 586-593

    • DOI

      10.1002/jhbp.208

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] G-cell hyperplasia of the stomach induces ECL-cell proliferation in the pyloric glands in a paracrinal manner2015

    • Author(s)
      Kasajima, A. Fujishima, F. Morikawa, T. Kawasaki, S. Konosu-Fukaya, S. Shibahara, Y. Nakamura, T. Yoshikawa, T. Iijima, K. Koike, T. Watanabe, M. Shibata, C. Sasano, H.
    • Journal Title

      Pathology International

      Volume: 65 Issue: 5 Pages: 259-63

    • DOI

      10.1111/pin.12276

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Angiogenesis and vascular maturation in neuroendocrine tumors2014

    • Author(s)
      Yazdani, S. Kasajima, A. Tamaki, K. Nakamura, Y. Fujishima, F. Ohtsuka, H. Motoi, F. Unno, M. Watanabe, M. Sato, Y. Sasano, H.
    • Journal Title

      Human Pathology

      Volume: 45 Issue: 4 Pages: 866-74

    • DOI

      10.1016/j.humpath.2013.09.024

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oncocytic adrenocortical neoplasm arising from adrenal rest in the broad ligament of the uterus2014

    • Author(s)
      Kasajima, A. Nakamura, Y. Adachi, Y. Takahashi, Y. Fujishima, F. Chiba, Y. Uehara, S. Watanabe, M. Sasano, H.
    • Journal Title

      Pathology International

      Volume: 4 Issue: 4 Pages: 183-8

    • DOI

      10.1111/pin.12154

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Prognostic and anti-tumoral significance of inflammatory reaction in broncho-pulmonary neuroendocrine neoplasms2017

    • Author(s)
      Atsuko Kasajima, Ayaka Iwata, Naomi Oka, Hirotaka Ishida, Akira Sakurada, Toru Kameya, Yuichi Ishikawa, Katja Steiger, Bjoern Konukiewitz, Guenter Kloeppel, Yoshinori Okada, Hironobu Sasano, Wilko Weichert
    • Organizer
      101. Jahrestagung der Deutschen Geselschaft der Pathologie
    • Place of Presentation
      Erlamgen, Germany
    • Year and Date
      2017-07-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Multiple pancreatic neuroendocrine neoplasms; What pathologists should consider?2017

    • Author(s)
      Atsuko Kasajima, Satoko Sato, Tomoyoshi Tachibana, Samaneh Yazdani, Bjoern Konukiewitz, Wilko Weichert, Guenter Kloeppel, Hironobu Sasano
    • Organizer
      10th Asia Pacific IAP Congress 2017
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2017-04-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Prognosis and Incidence in Pancreatic and Gastrointestinal Neuroendocrine Neoplasms with emphasis on “NET G3”: An analysis of 198 cases from Japan2017

    • Author(s)
      Atsuko Kasajima, Tomoyoshi Tachibana, Hirotaka Ishida, Samaneh Yazdani, Bjoern Konukiewitz, Guenter Kloeppel, Wilko Weichert, Hironobu Sasano
    • Organizer
      14th European Neuroendocrine Tumor Society
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Atsuko Kasajima, Naomi Oka, Hirotaka Ishida, Akira Sakurada, Toru Kameya, Bjoern Konukiewitz, Guenter Kloeppel, Wilko Weichert, Yuichi Ishikawa, Yoshinori Okada, Hironobu Sasano2017

    • Author(s)
      Classification of lung neuroendocrine neoplasms (Lung-NENs) according to WHO 2010 for gastroenteropancreatic NENs (GEP-NENs) has prognostic relevance and includes Lung-NETs G3.
    • Organizer
      14th European Neuroendocrine Tumor Society
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食道および肺小細胞癌に共通する免疫組織学的な腺上皮分化2016

    • Author(s)
      石田 裕嵩, 笠島 敦子, 亀井 尚, 岡 直美, サマネ・ヤズダニ, 藤島 史喜,  桜田 晃, 中村 保宏, 田中 洋一, 黒住 昌史, 石川 雄一, 岡田 克典, 大内 憲明, 笹野 公伸
    • Organizer
      第4回日本神経内分泌腫瘍研究会学術集会
    • Place of Presentation
      東京大学伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 免疫組織化学によるSomatostatin receptor (SSTR) の施設・観察者間一致性に関する検討2016

    • Author(s)
      伊藤渉, 笠島敦子, 橘知睦, Samaneh Yazdani, Mauro Papotti, Marco Volante, 笹野公伸
    • Organizer
      第4回日本神経内分泌腫瘍研究会学術集会
    • Place of Presentation
      東京大学伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 岡 直美,笠島 敦子, 石田 裕嵩, サマネ ヤズダニ, 桜田 晃, 櫻田 潤子, 鈴木 博義, 石川 雄一, 岡田 克典, 笹野 公伸2016

    • Author(s)
      肺神経内分泌腫瘍197症例の臨床病理組織学的検討
    • Organizer
      第4回日本神経内分泌腫瘍研究会学術集会
    • Place of Presentation
      東京大学伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Progesterone Receptor Isoform A Inhibits Cyclin B1 Expression in Pancreatic Neuroendocrine Tumor2016

    • Author(s)
      Samaneh Yazdani, Atsuko Kasajima, Hironobu Sasano
    • Organizer
      第4回日本神経内分泌腫瘍研究会学術集会
    • Place of Presentation
      東京大学伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膵消化管神経内分泌腫瘍 Gastroenteropancreatic Neuroendocrine Tumor : GEP-NET 病理診断 up-to-date2015

    • Author(s)
      笠島敦子
    • Organizer
      日本消化器病学会東北支部会 第17回教育講演会
    • Place of Presentation
      ホテルメトロポリタン盛岡、岩手
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Profiling of cell cycle pathway genes in pancreatic neuroendocrine tumor cell line after treatment with progesterone.2015

    • Author(s)
      Yazdani S, Kasajima A, Sasano H.
    • Organizer
      3rd Congress on Steroid Research
    • Place of Presentation
      Hyatt Regency McCormick Place, Chicago, USA
    • Year and Date
      2015-11-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 膵EUS-FNAにおける 膵神経内分泌腫瘍と形態の類似する膵病変の 免疫組織化学を用いた鑑別診断2015

    • Author(s)
      笠島敦子、笹野公伸
    • Organizer
      第56回日本組織細胞化学学会学術総会
    • Place of Presentation
      関西医科大学枚方病院、大阪
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] EUS-FNAにおける膵NETの病理診断2015

    • Author(s)
      笠島敦子、安達友津、小泉輝樹、三浦弘守、 菅野敦、藤島史喜、笹野公伸
    • Organizer
      第三回日本神経内分泌腫瘍研究会学術集会
    • Place of Presentation
      仙台市民会館、仙台、宮城
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] Progesterone-induced cell cycle gene expression profiling by PCR array in pancreatic neuroendocrine tumor cell line.2015

    • Author(s)
      Yazdani S, Kasajima A, Sasano H.
    • Organizer
      第三回日本神経内分泌腫瘍研究会学術集会
    • Place of Presentation
      仙台市民会館、仙台、宮城
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] Interesting Case Presentations: A case of multiple gastrointestinal endocrine and non-endocrine neoplasms2015

    • Author(s)
      Atsuko Kasajima, Hironobu Sasano
    • Organizer
      Asia Pacific international academy of Pathology
    • Place of Presentation
      Brisbane Convention & Exhibition Centre, Brisbane, Queensland, Australia.
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ファーター乳頭部領域腫瘍 - 概念と診断 -非外分泌腫瘍 神経内分泌腫瘍を中心に2015

    • Author(s)
      笠島敦子、笹野公伸
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場、愛知
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Presentation] Progesterone Receptor Isoforms A and B in Pancreatic Neuroendocrine Tumor2015

    • Author(s)
      Yazdani S, Kasajima A, Felizola S JA, Onodera Y, Nakamura Y, Sasano H.
    • Organizer
      ENDO2015: The endocrine Society annual meeting
    • Place of Presentation
      San Diego, California
    • Year and Date
      2015-04-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経内分泌腫瘍の病理診断:現状と課題 S1-4. 神経内分泌腫瘍におけるKi67 labeling indexに関する最近の話題Ki67の自動計測の実用化にむけた課題.2014

    • Author(s)
      笠島敦子, 佐藤聡子, 山崎有人, 笹野公伸.
    • Organizer
      第18回日本内分泌病理学会学術集会
    • Place of Presentation
      東京, 都道府県会館
    • Year and Date
      2014-11-01
    • Related Report
      2014 Research-status Report
  • [Presentation] A case of hypergastrinemia.2014

    • Author(s)
      Kasajima A, Sasano H.
    • Organizer
      The 5th Taiwan-Japanese Conjoint Slide Conference of the International Academy of Pathology.
    • Place of Presentation
      Taipei, Howard Civil Service International House
    • Year and Date
      2014-10-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Pancreatic neuroendocrine tumor, oncocytic variant.2014

    • Author(s)
      Kasajima A, Sasano H.
    • Organizer
      International academy of pathology 2014
    • Place of Presentation
      Bangkok, Bangkok Convention Centre at Centralworld
    • Year and Date
      2014-10-05 – 2014-10-10
    • Related Report
      2014 Research-status Report
  • [Presentation] EUS-FNA検体で病理診断を行う際の注意事項と最近のトピックス.2014

    • Author(s)
      笠島敦子, 笹野公伸
    • Organizer
      第2回日本神経内分泌腫瘍研究会学術集会.
    • Place of Presentation
      東京, 東京大学伊藤国際学術研究センター
    • Year and Date
      2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] EUS-FNAにおける膵腫瘍の細胞診断 solid-pseudopapillary neoplasmとneuroendocrine neoplasmの鑑別について2014

    • Author(s)
      安達友津, 三浦弘守, 笠島敦子, 谷内真司, 藤島史喜, 渡辺みか, 笹野公伸
    • Organizer
      第51回日本臨床細胞学会東北支部連合会学術集会.
    • Place of Presentation
      秋田, 秋田県総合保健センター
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report
  • [Presentation] The current Status of Pancreatic Neuroendocrine Tumors. Histopathological features and WHO classification of PNET.2014

    • Author(s)
      Kasajima A, Sasano H
    • Organizer
      The 87th Annual Meeting of the Japan Endocrine Society
    • Place of Presentation
      Fukuoka, Fukuoka Convention Centre
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 内分泌病理から臨床へのフィードバック. 膵消化管神経内分泌腫瘍のWHO分類.2014

    • Author(s)
      笠島敦子, 笹野公伸
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡, 福岡国際会議場
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Book] 消化管NET 第1部-第3部2017

    • Author(s)
      笠島 敦子 笹野 公伸
    • Total Pages
      20
    • Publisher
      腫瘍病理鑑別疾患アトラス 内分泌
    • Related Report
      2016 Annual Research Report
  • [Book] WHO2010分類の妥当性と今後の病理診断の展望2016

    • Author(s)
      笠島 敦子 笹野 公伸
    • Total Pages
      4
    • Publisher
      胆と膵
    • Related Report
      2016 Annual Research Report
  • [Book] 腫瘍病理鑑別診断アトラス 胆道癌・膵癌2015

    • Author(s)
      笠島敦子, 笹野公伸
    • Total Pages
      6
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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