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Molecular and morphologic features of uterine adenocarcinoma

Research Project

Project/Area Number 26460419
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionKyushu University

Principal Investigator

Ohishi Yoshihiro  九州大学, 医学研究院, 准教授 (60444824)

Research Collaborator Wada Tomoko  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords子宮腺癌 / 子宮頸部通常型腺癌 / 子宮頸部胃型腺癌 / Human papillomavirus / p16 / p53 / HIK1083 / 子宮体癌 / 類内膜癌 / 異型度 / 腺癌の亜型分類 / 通常型腺癌 / 胃型腺癌
Outline of Final Research Achievements

WHO classification set up new entities of endocervical adenocarcinoma (ECA), namely the 'usual type' and 'gastric type.' Usual-type ECAs (U-ECAs) are virtually always associated with high-risk human papillomavirus (HR-HPV) infection. Gastric-type ECAs (G-ECAs) are believed not to be associated with HR-HPV infection. We noticed that some ECAs contain morphologically usual type-like and gastric type-like components in a single tumor; we have named these "G+U" ECAs. We analyzed 70 cases of endocervical adenocarcinoma. We identified 48 pure U-ECAs, nine pure G-ECAs and 13 G+U ECAs. Most G+U ECAs showed no HR-HPV infection and showed frequent HIK1083 expression and aberrant p53 expression. The other G+U ECAs showed HR-HPV infection and frequent p16+/p53-/HIK1083-; immunophenotype. Most of the G+U ECAs we examined were genuine HPV-unrelated G-ECAs with usual type-like components. A small population of G+U ECAs was genuine HPV-related U-ECAs with gastric type-like components.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 4 results) Presentation (1 results)

  • [Journal Article] Endocervical Adenocarcinoma With Morphologic Features of Both Usual and Gastric Types: Clinicopathologic and Immunohistochemical Analyses and High-risk HPV Detection by In Situ Hybridization.2017

    • Author(s)
      Wada T, Ohishi Y, Kaku T, Aman M, Imamura H, Yasutake N, Sonoda K, Kato K, Oda Y.
    • Journal Title

      Am J Surg Pathol.

      Volume: 41 Issue: 5 Pages: 696-705

    • DOI

      10.1097/pas.0000000000000833

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular characteristics of colorectal neuroendocrine carcinoma2015

    • Author(s)
      Takizawa N, Ohishi Y et al.
    • Journal Title

      Human Pathology

      Volume: 46 (12) Issue: 12 Pages: 1890-1900

    • DOI

      10.1016/j.humpath.2015.08.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ovarian high-grade serous carcinoma with a noninvasive growth pattern simulating a serous borderline tumor.2015

    • Author(s)
      Imamura H, Ohishi Y et al.
    • Journal Title

      Human Pathology

      Volume: 46 (10) Issue: 10 Pages: 1455-1463

    • DOI

      10.1016/j.humpath.2015.06.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of intranuclear inclusions is useful for the cytological diagnosis of ovarian clear cell carcinoma.2015

    • Author(s)
      Naka M, Ohishi Y et al.
    • Journal Title

      Diagn Cytopathol.

      Volume: 43 (11) Issue: 11 Pages: 879-884

    • DOI

      10.1002/dc.23322

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Is Invasive Micropapillary Serous Carcinoma a Low-grade Carcinoma ?2014

    • Author(s)
      Yoshihiro Ohishi
    • Journal Title

      International Journal of Gynecological Pathology

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 通常型と胃型、両者に類似した形態が混在する子宮頸部腺癌の検討2016

    • Author(s)
      篠崎智子、大石善丈、小田義直
    • Organizer
      第105回日本病理学会
    • Place of Presentation
      仙台
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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