Screening of therapeutic targets in diffuse type gastric cancer

• Project/Area Number: 26460420
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Oita University
• Principal Investigator: Murakami Kazunari 大分大学, 医学部, 教授 (00239485)
• Co-Investigator(Kenkyū-buntansha): 兒玉 雅明 大分大学, 福祉健康科学部, 教授 (20332893) ; 守山 正胤 大分大学, 医学部, 教授 (90239707) ; 沖本 忠義 大分大学, 医学部, 講師 (90381037)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 低分化型胃癌 / アレイCGH / 標的遺伝子 / 胃癌 / FGFR

Outline of Final Research Achievements

Gastric cancer (GC) remains one of the most common malignant diseases, with an estimated annual mortality of 700 000 worldwide, ranking third after lung and liver cancer Despite a number of chemotherapy regimens using cytotoxic drugs, the prognosis of patients with advanced disease is still disappointing. Especially, diffuse type GC shows more malignant behavior, such as metastasis to lymph node or peritoneal and resistance to chemotherapy, than differentiated GC. In this study, we aimed to establish the molecular targeted therapy for diffuse type GC. For this aim, we first compared alterations in genomic copy number, gene expression profile and phosphorylation of several proteins between diffuse type and differentiated type GCs. Secondly, we analyzed the contribution of candidate alterations on the malignancy. In conclusion, we found several candidates for the molecular targeted therapy in diffuse type GC.

Research Products

• [Journal Article] Kidney-specific knockout of Sav1 in the mouse promotes hyper-proliferation of renal tubular epithelium through suppression of the Hippo pathway. (2016)
  • Author(s): Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, Daa T, Iha H, Takahashi M, Nomura T, Sato F, Mimata H, Ikawa M, Seto M, Matsuura K, Moriyama M.
  • Journal Title: J Pathol. Volume: 印刷中 Issue: 1 Pages: 97-108
  • DOI: 10.1002/path.4706
  • Peer Reviewed / Open Access
• [Journal Article] Genomic loss of DUSP4 contributes to the progression of intraepithelial neoplasm of pancreas to invasive carcinoma. (2016)
  • Author(s): Hijiya N, Tsukamoto Y, Nakada C, Tung NL, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, Moriyama M.
  • Journal Title: Cancer Res. Volume: 76 Issue: 9 Pages: 2612-2625
  • DOI: 10.1158/0008-5472.can-15-1846
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma. (2016)
  • Author(s): Takahashi M, Tsukamoto Y, Kai T, Tokunaga A, Nakada C, Hijiya N, Uchida T, Daa T, Nomura T, Sato F, Mimata H, Matsuura K, Moriyama M.
  • Journal Title: Cancer Science Volume: 107(4) Issue: 4 Pages: 417-423
  • DOI: 10.1111/cas.12892
  • Peer Reviewed / Open Access
• [Journal Article] Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells. (2016)
  • Author(s): Hirashita Y, Kodama M, Okimoto T, Murakami K, Moriyama M, et al.
  • Journal Title: Cancer Science Volume: 107(12) Issue: 12 Pages: 1919-1928
  • DOI: 10.1111/cas.13094
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, double-blind study. (2016)
  • Author(s): Murakami K, Sakurai Y, Shiino M, Funao N, et al.
  • Journal Title: Gut Volume: 65(9) Issue: 9 Pages: 1439-1446
  • DOI: 10.1136/gutjnl-2015-311304
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Esomeprazole- or rabeprazole-based triple therapy eradicated <i>Helicobacter pylori</i> comparably regardless of clarithromycin susceptibility and CYP2C19 genotypes (2016)
  • Author(s): Okimoto T, Mizukami K, Kodama M, Murakami K, et al.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 59 Issue: 2 Pages: 149-153
  • DOI: 10.3164/jcbn.16-18
  • NAID: 130005262392
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Two cases of adenocarcinoma occurring in sporadic fundic gland polyps observed by magnifying endoscopy with narrow band imaging (2016)
  • Author(s): Togo K, Ueo T, Yonemasu H, Murakami K, et al.
  • Journal Title: World Journal of Gastroenterology. Volume: 22(40) Issue: 40 Pages: 9028-9034
  • DOI: 10.3748/wjg.v22.i40.9028
  • Peer Reviewed / Open Access
• [Journal Article] Differences in amino acid frequency in CagA and VacA sequences of <i>Helicobacter pylori</i> distinguish gastric cancer from gastric MALT lymphoma. (2016)
  • Author(s): Hashinaga M, Suzuki R, Akada J, Matsumoto T, Kido Y, Okimoto T, Kodama M, Murakami K, Yamaoka Y
  • Journal Title: Gut Pathog. Volume: 8:54 Issue: 1 Pages: 1-10
  • DOI: 10.1186/s13099-016-0137-x
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Helicobacter pylori感染症認定医スキルアップ講座 P-CABのHelicobacter pylori 除菌治療への使用 (2016)
  • Author(s): 村上和成
  • Journal Title: Helicobacter Research Volume: 20(1) Pages: 89-91
• [Journal Article] Evidence-based clinical practice guidelines for peptic ulcer disease 2015 (2016)
  • Author(s): Satoh K, Yoshino J, Akamatsu T, Itoh T, Kato M, Kamada T, Takagi A, Chiba T, Nomura S, Mizokami Y, Murakami K, Sakamoto C, Hiraishi H, Ichinose M, Uemura N, Goto H, Joh T, Miwa H, Sugano K, Shimosegawa T
  • Journal Title: Journal of Gastroenterol Volume: 51 Issue: 3 Pages: 177-194
  • DOI: 10.1007/s00535-016-1166-4
  • Peer Reviewed
• [Journal Article] Kyoto global consensus report on Helicobacter pylori gastritis. (2015)
  • Author(s): Sugano K, Tack J, Kuipers EJ, Murakami K et.al
  • Journal Title: Gut Volume: 64 Issue: 9 Pages: 1353-1367
  • DOI: 10.1136/gutjnl-2015-309252
  • Peer Reviewed / Open Access
• [Journal Article] Relationships between Causes of Fever of Unknown Origin and Inflammatory Markers: A Multicenter Collaborative Retrospective Study (2015)
  • Author(s): Naito T, Torikai K, Mizooka M, Mitsumoto F, Kanazawa K, Ohno S, Morita H, Ukimura A, Mishima N, Otsuka F, Ohyama Y, Nara N, Murakami K, Mashiba K, Akazawa K, Yamamoto K, Tanei M, Yamanouchi M, Senda S, Tazuma S, Hayashi J.
  • Journal Title: Internal Medicine Volume: 54 Issue: 16 Pages: 1989-1994
  • DOI: 10.2169/internalmedicine.54.3313
  • NAID: 130005092893
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Endoscopic atrophic classification before and after H. pylori eradication is closely associated with histological atrophy and intestinal metaplasia. (2015)
  • Author(s): Kodama M, Okimoto T, Ogawa R, Mizukami K, Murakami K.
  • Journal Title: Endoscopy International Open Volume: 3 Issue: 04 Pages: 311-317
  • DOI: 10.1055/s-0034-1392090
  • Peer Reviewed / Open Access
• [Journal Article] Benefits of nucleos(t)ide analog treatments for hepatitis B virus-related cirrhosis (2015)
  • Author(s): Honda K, Seike M, Murakami K
  • Journal Title: World Journal of Hepatology Volume: 7 Issue: 22 Pages: 2404-2410
  • DOI: 10.4254/wjh.v7.i22.2404
  • Peer Reviewed
• [Journal Article] Histologic differentiation and mucin phenotype in white opaque substance-positive gastric neoplasias (2015)
  • Author(s): Ueo T, Yonemasu H, Yao K, Ishida T, Togo K, Yanai Y, Fukuda M, Motomura M, Narita R, Murakami K
  • Journal Title: Endoscopy International Open Volume: 03 Issue: 06 Pages: 597-604
  • DOI: 10.1055/s-0034-1393177
  • Peer Reviewed
• [Journal Article] Expression of DDX27 contributes to colony-forming ability of gastric cancer cells and correlates with poor prognosis in gastric cancer. (2015)
  • Author(s): Tsukamoto Y, Fumoto S, Noguchi T, Yanagihara K, Hirashita Y, Nakada C, Hijiya N, Uchida T, Matsuura K, Hamanaka R, Murakami K, Seto M, Inomata M, Moriyama M.
  • Journal Title: Am J Cancer Res Volume: 5 Pages: 2998-3014
  • Peer Reviewed
• [Journal Article] Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study. (2015)
  • Author(s): Matsuhashi N, Kudo M, Yoshida N, Murakami K, Kato M, Sanuki T, Oshio A, Joh T, Higuchi K, Haruma K, Nakada K
  • Journal Title: Journal of Gastroenterol Volume: 50 Issue: 12 Pages: 1173-1183
  • DOI: 10.1007/s00535-015-1073-0
  • Peer Reviewed
• [Journal Article] Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma. (2015)
  • Author(s): Narimatsu T, *Matsuura K, Nakada C, Tsukamoto Y, Hijiya N, Kai T, Inoue T, Uchida T, Nomura T, Sato F, Seto M, Takeuchi I, Mimata H, Moriyama M
  • Journal Title: Cancer Medicine Volume: 4(1) Issue: 1 Pages: 112-124
  • DOI: 10.1002/cam4.351
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enhanced miR-210 expression promotes the pathogenesis of endometriosis through activation of signal transducer and activator of transcription 3. (2015)
  • Author(s): Okamoto M, Nasu K, Abe W, Aoyagi Y, Kawano Y, Kai K, Moriyama M et al.
  • Journal Title: JOURNAL OF Human Reproduction Volume: 30 Issue: 3 Pages: 632-641
  • DOI: 10.1093/humrep/deu332
  • Peer Reviewed
• [Journal Article] Serum Helicobacter pylori CagA antibody titer as a useful marker for advanced inflammation in the stomach in Japan (2014)
  • Author(s): Shiota S, Murakami K, Okimoto T, Kodama M, Yamaoka Y
  • Journal Title: J Gastroenterol Hepatol Volume: 29 Issue: 1 Pages: 67-73
  • DOI: 10.1111/jgh.12359
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of Helicobacter pylori infection by birth year and geographic area in Japan. (2014)
  • Author(s): Ueda J, Gosho M, Inui Y, Matsuda T, Sakakibara M, Mabe K, Nakajima S, Shimoyama T, Yasuda M, Kawai T, Murakami K, Kamada T, Mizuno M, Kikuchi S, Lin Y, Kato M.
  • Journal Title: Helicobacter Volume: 19(2) Issue: 2 Pages: 105-110
  • DOI: 10.1111/hel.12110
  • Peer Reviewed
• [Journal Article] Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment. (2014)
  • Author(s): Fujimoto K, Fujishiro M, Kato M, Higuchi K, Iwakiri R, Sakamoto C, Uchiyama S, Kashiwagi A, Ogawa H, Murakami K, Mine T, Yoshino J, Kinoshita Y, Ichinose M, Matsui T.
  • Journal Title: Digestive Endoscopy Volume: 26 Issue: 1 Pages: 1-14
  • DOI: 10.1111/den.12183
  • Peer Reviewed
• [Journal Article] Adjunct antibiotic combination therapy for steroid-refractory or-dependent ulcerative colitis: an open-label multicenter study. (2014)
  • Author(s): Kato K, Ohkusa T, Terao S, Chiba T, Murakami K, Yanaka A, Uehara T, Ishii Y, Soma M, Tajiri H.
  • Journal Title: Aliment Pharmacol Ther Volume: 39 Issue: 9 Pages: 949-956
  • DOI: 10.1111/apt.12688
  • Peer Reviewed
• [Journal Article] A randomized placebo-controlled, double-blind clinical trial of rikkunshito for patients with non-erosive reflux disease refractory to proton-pump inhibitor: the G-PRIDE study (2014)
  • Author(s): K. Tominaga, M. Kato, H. Takeda, Y. Shimoyama, E. Umegaki, R. Iwakiri, K. Furuta, K. Sakurai, T. Odaka, H. Kusunoki, A. Nagahara, K. Iwakiri, T. Furuta, K. Murakami, H. Miwa, Y. Kinoshita, K. Haruma, S. Takahashi, S. Watanabe, K. Higuchi, M. Kusano, K. Fujimoto, T. Arakawa
  • Journal Title: Journal of Gastroenterology Volume: 49 Issue: 10 Pages: 1392-1405
  • DOI: 10.1007/s00535-013-0896-9
  • Peer Reviewed
• [Journal Article] Multiple infections with helminthes -whipworm, hookworm, and roundworm (2013)
  • Author(s): Kunimitsu Inoue, Sotaro Ozaka, Kazuhisa Okamoto, Ryu Ogawa, Kazuhiro Mizukami, Tadayoshi Okimoto, Masaaki Kodama, Takashi Kobayashi, Yuki Eshita, Hideo Hasegawa, Kazunari Murakami
  • Journal Title: Endoscopy Volume: 46 Issue: S 01 Pages: 117-118
  • DOI: 10.1055/s-0034-1364887
  • Peer Reviewed / Open Access
• [Presentation] 17 cases of helicobacter pylori infection negative gastric cancer (2017)
  • Author(s): Okamoto K, Kodama M, Okimoto T, Murakami K, et al.
  • Organizer: World Congress of Gastrointestinal Endoscopy ENDO 2017
  • Place of Presentation: インド・ハイデラバード、Hyderabad International Convention Center
  • Year and Date: 2017-02-16
  • Int'l Joint Research
• [Presentation] Relationship between endoscopic atrophic classification and histological atrophy and intestinal metaplasia. (2016)
  • Author(s): Kodama M, Okimoto T, Murakami K, et al.
  • Organizer: Asian Pacific Digestive Week 2016
  • Place of Presentation: 兵庫県、神戸コンベンションセンター
  • Year and Date: 2016-11-02
  • Int'l Joint Research
• [Presentation] Esomeprazole- or rabeprazole-based triple therapy eradicated Helicobacter pylori comparably regardless of clarithromycin susceptibility and CYP2C19 genotypes (2016)
  • Author(s): Okimoto T, Kodama M, Murakami K, et al.
  • Organizer: ACG 2016 Annual Scientific Meeting & Postgraduate Course
  • Place of Presentation: アメリカ合衆国ラスベガス
  • Year and Date: 2016-10-14
  • Int'l Joint Research
• [Presentation] Utility of gastroendoscopy for subjects with serum H.pylori antibody (IgG) titer equal or more than 3.0 U/ml- Study of endoscopic findings for titers between 3.0 and 9.9 U/ml (so-called “gray zone”) - (2016)
  • Author(s): Shuto M, Murakami K, Okimoto T, Kodama M, et al.
  • Organizer: XXIXth International Workshop on Helicobacter and Microbiota in Inflammation and Cancer
  • Place of Presentation: ドイツマクデブルグ
  • Year and Date: 2016-09-15
  • Int'l Joint Research
• [Presentation] H.pylori除菌前後における内視鏡学的胃粘膜萎縮分類と組織学的萎縮・腸上皮化生との相関の変化に関する検討 (2016)
  • Author(s): 兒玉雅明、沖本忠義、村上和成、他
  • Organizer: 第22回日本ヘリコバクター学会学術集会
  • Place of Presentation: 大分県、別府ビーコンプラザ
  • Year and Date: 2016-06-24
  • Int'l Joint Research
• [Presentation] H.pylori除菌後発見胃癌における除菌時高リスク因子による除菌後胃癌リスクスコアの策定 (2016)
  • Author(s): 兒玉雅明、沖本忠義、村上和成、他
  • Organizer: 第22回日本ヘリコバクター学会学術集会
  • Place of Presentation: 大分県、別府ビーコンプラザ
  • Year and Date: 2016-06-24
  • Int'l Joint Research
• [Presentation] 当院および関連施設におけるピロリ菌未感染胃癌12例のまとめとピロリ菌感染胃癌、除菌後胃癌との比較 (2016)
  • Author(s): 岡本和久、兒玉雅明、沖本忠義、村上和成、他
  • Organizer: 第22回日本ヘリコバクター学会学術集会
  • Place of Presentation: 大分県、別府ビーコンプラザ
  • Year and Date: 2016-06-24
  • Int'l Joint Research
• [Presentation] 実地医家における血清抗ピロリ菌抗体を参考にした内視鏡診療の有り方について (2016)
  • Author(s): 首藤充孝、藤岡利生、村上和成
  • Organizer: 第91回日本消化器内視鏡学会総会
  • Place of Presentation: 東京都、グランドプリンスホテル新高輪
  • Year and Date: 2016-05-12
• [Presentation] H. pylori除菌後発見胃癌における早期癌と進行癌の臨床病理学的差異の検討 (2016)
  • Author(s): 兒玉雅明、沖本忠義、村上和成
  • Organizer: 第91回日本消化器内視鏡学会総会
  • Place of Presentation: 東京都、グランドプリンスホテル新高輪
  • Year and Date: 2016-05-12
• [Presentation] ボノプラザン（タケキャブ）を用いた除菌治療の成績 (2016)
  • Author(s): 松成修、沖本忠義、兒玉雅明、村上和成、他
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 東京都、京王プラザホテル
  • Year and Date: 2016-04-21
• [Presentation] 次世代シーケンサーを用いたH.pylori除菌後胃癌の網羅的遺伝子解析による除菌後胃癌危険因子の検討 (2016)
  • Author(s): 兒玉雅明、沖本忠義、村上和成
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 東京都、京王プラザホテル
  • Year and Date: 2016-04-21
• [Presentation] 胃癌におけるMEK阻害剤への感受性予測因子の探索 (2016)
  • Author(s): 平下有香、沖本忠義、兒玉雅明、守山正胤、村上和成、他
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 東京都、京王プラザホテル
  • Year and Date: 2016-04-21
• [Presentation] Clinicopathological Characteristics of Gastric Cancer following H. pylori Eradication- from Kyoto Global Consensus Meeting (2016)
  • Author(s): Murakami K
  • Organizer: The 3rd China- Japan Medical Exchange ( Gastroenterology ) Forum
  • Place of Presentation: 中国蘇州、Suzhou International Expo Center
  • Int'l Joint Research
• [Presentation] H.pylori感染胃炎の診断と治療 (2015)
  • Author(s): 村上和成
  • Organizer: 第23回日本消化器関連学会週間
  • Place of Presentation: グランドプリンスホテル新高輪（東京都、港区）
  • Year and Date: 2015-10-08
• [Presentation] ヘリコバクター・ピロリ除菌後再出現に対する検討 (2015)
  • Author(s): 沖本忠義、兒玉雅明、村上和成
  • Organizer: 第90回日本消化器内視鏡学会総会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都、港区）
  • Year and Date: 2015-10-08
• [Presentation] 大分県における病院受診若年者のピロリ菌感染率と感染経路の解明 (2015)
  • Author(s): 塩田星児、沖本忠義、兒玉雅明、村上和成
  • Organizer: 第21回日本ヘリコバクター学会学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県、神戸市）
  • Year and Date: 2015-06-26
• [Presentation] 萎縮性胃炎とくに萎縮境界に関するLinked Color Imaging (LCI)の有用性 (2015)
  • Author(s): 水上一弘、小川竜、岡本和久、首藤充孝、和田蔵人、橋永正彦、沖本忠義、兒玉雅明、村上和成
  • Organizer: 第21回日本ヘリコバクター学会学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県、神戸市）
  • Year and Date: 2015-06-26
• [Presentation] H. pylori除菌後発見胃癌における内視鏡的および免疫組織学的特徴の検討 (2015)
  • Author(s): 兒玉雅明、沖本忠義、村上和成
  • Organizer: 第89回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋国際会議場（愛知県、名古屋市）
  • Year and Date: 2015-05-29
• [Presentation] The recurrence and clarithromycin resistant rate of Helicobacter pylori after successful eradication therapy in Japan (2015)
  • Author(s): Tadayoshi Okimoto
  • Organizer: Digestive Disease Week 2015（米国消化器病週間）
  • Place of Presentation: アメリカ合衆国、ワシントン、ウォルター・E・ワシントン・コンベンションセンター
  • Year and Date: 2015-05-16
• [Presentation] ピロリ菌除菌後の問題点 H.pylori除菌は胃癌発症を抑制するか H.pylori除菌後経過期間による除菌後胃癌の形態学的および免疫組織学的形質差異の検討 (2015)
  • Author(s): 兒玉 雅明, 小川 竜, 村上 和成
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台国際センター（宮城県、仙台市）
  • Year and Date: 2015-04-23
• [Presentation] A Phase 3, Double-Blind Study of a Triple Therapy with TAK-438, Amoxicillin, and Clarithromycin As First Line Eradication of H. pylori and a Triple Therapy With TAK-438, Amoxicillin, and Metronidazole As Second Line Eradication of H. pylori (2014)
  • Author(s): Murakami K, Skurai Y, Shiino M, Funao N, Nishimaru A, Asaka M
  • Organizer: Digestive Disease Week 2014
  • Place of Presentation: アメリカ合衆国、シカゴ
  • Year and Date: 2014-05-04
• [Presentation] Helicobacter pyloriと上部消化管疾患診療の変遷 (2014)
  • Author(s): 村上和成
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京都、千代田区）
  • Year and Date: 2014-04-26
  • Invited
• [Book] 消化器疾患最新の治療2017-2018 （消化性潰瘍 薬物治療指針） (2017)
  • Author(s): 村上和成
  • Total Pages: 514
  • Publisher: 南江堂
• [Book] 内科学書 改訂第8版（消化管の細菌学的検査） (2016)
  • Author(s): 村上和成
  • Publisher: 中山書店
• [Book] 胃炎の京都分類 (2014)
  • Author(s): 加藤 元嗣, 井上 和彦, 村上 和成, 鎌田 智有
  • Total Pages: 127
  • Publisher: 日本メディカルセンター
• [Book] 消化器病診療第2版 (2014)
  • Author(s): 「消化器病診療（第2版）」 編集委員会
  • Total Pages: 528
  • Publisher: 医学書院