Investigation of tumor microenvironment and signaling cascade of monocyte differentiation into macrophages.
Project/Area Number |
26460422
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Yokohama City University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
田中 玲子 千葉大学, 真菌医学研究センター, 助教 (60143319)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | がん関連遺伝子 / 染色体 / コピー数 / 前がん病変 / ovarian cancer / endometrial cancer / pathology / chemokine |
Outline of Final Research Achievements |
We investigated genotype-phenotype correlation in rare tumors, mainly those with FLCN germline mutations, using surgically resected specimens. Approximately 40% of tumors with FLCN germline mutations had second hits or loss of heterozygosities. Those without second hits also demonstrated suppressed expression of FLCN at protein level, indicating that mutant FLCN had dominant-negative effects. We successfully established some primary culture tumor cells from surgically resected renal tumors harboring FLCN germline mutations. We also established one immortalized cells using SV40T antigen.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Genetic, Epidemiologic and Clinicopathologic Studies of Japanese Asian Patients with Birt-Hogg-Dubé Syndrome2016
Author(s)
Furuya M, Yao M, Tanaka R, Nagashima Y, Kuroda N, Hasumi H, Baba M, Matsushima J, Nomura F, Nakatani Y
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Journal Title
Clin Genet
Volume: 90
Pages: 403-412
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Pulmonary Neoplasms in Patients with Birt-Hogg-Dubé Syndrome: Histopathological Features and Genetic and Somatic Events.2016
Author(s)
Furuya M, Tanaka R, Okudela K, Nakamura S, Yoshioka H, Tsuzuki T, Shibuya R, Yatera K, Shirasaki H, Sudo Y, Kimura N, Yamada K, Uematsu S, Kunimura T, Kato I, Nakatani Y
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Journal Title
PLos One
Volume: 11
Pages: e0151476
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Intratumoral peripheral small papillary tuft (ITPSPT): A diagnostic clue of renal tumors associated with Birt-Hogg-Dubé syndrome.2014
Author(s)
Kuroda N, Furuya M, Nagashima Y, Gotoda H, Moritani S, Kawakami F, Imamura Y, Bando Y, Takahashi M, Kanayama H, Ota S, Michal M, Hes O, Nakatani Y
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Journal Title
Ann Diagn Pathol
Volume: 18
Pages: 171-176
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Review of Renal Tumors associated with Birt-Hogg-Dubé syndrome with focus on clinical and pathobiological aspects.2014
Author(s)
Kuroda N, Furuya M, Nagashima Y, Gotoda H, Kawakami F, Moritani S, Ota S, Hora M, Michal M, Hes O, Nakatani Y
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Journal Title
Pol J Pathol
Volume: 66
Pages: 93-99
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clear cell papillary renal cell carcinoma: a review.2014
Author(s)
Kuroda N, Ohe C, Kawakami F, Mikami S, Furuya M, Matsuura K, Moriyama M, Nagashima Y, Zhou M, Petersson F, Lopez J, Hes O, Michal M, Amin MB
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Journal Title
Int J Clin Exp Pathol
Volume: 7
Pages: 7312-7318
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Book] 生体の科学2016
Author(s)
古屋充子
Total Pages
595(462-463)
Publisher
公益財団法人金原一郎医学医療振興財団
Related Report
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[Book] 臨床画像2015
Author(s)
古屋充子, 中谷行雄
Total Pages
5
Publisher
メジカルビュー
Related Report
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