SWI/SNF chromatin remodeling complex status in soft tissue tumors

• Project/Area Number: 26460435
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kyushu University
• Principal Investigator: Kohashi Kenichi 九州大学, 医学研究院, 講師 (10529879)
• Co-Investigator(Kenkyū-buntansha): 山元 英崇 九州大学, 大学病院, 准教授 (30404073)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 悪性ラブドイド腫瘍 / 類上皮肉腫 / SMARCB1/INI1 / SWI/SNF型クロマチン再構成因子複合体 / SWI/SNF / 尿路上皮癌 / ラブドイド / BRG1 / BAF155 / BAF170

Outline of Final Research Achievements

SWI/SNF chromatin remodeling complex is composed of evolutionarily conserved core subunits: SMARCB1/INI1, SMARCA4/BRG1, SMARCC1/BAF155 and SMARCC2/BAF170. Although complete loss of SMARCB1/INI1 protein expression has been demonstrated in almost all epithelioid sarcoma (ES) and malignant rhabdoid tumor (MRT) cases, some cases of SMARCB1/INI1-preserved ES and MRT identified. In addition, ES and MRT cases showed various immunoexpression patterns, such as reduced or complete loss pattern, of core subunit proteins of this complex. Therefore, combined reduced expressions of these proteins may have an important role in tumorigenesis in these tumors.

Research Products

• [Journal Article] Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status. (2017)
  • Author(s): Yamashita K, Kohashi K, Yamada Y, Nishida Y, Urakawa H, Oda Y, Toyokuni S.
  • Journal Title: Hum Pathol. Volume: 印刷中 Pages: 63-69
  • DOI: 10.1016/j.humpath.2017.02.007
  • Peer Reviewed
• [Journal Article] Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes. (2017)
  • Author(s): Yamada Y, Kuda M, Kohashi K, Yamamoto H, Takemoto J, Ishii T, Iura K, Maekawa A, Bekki H, Ito T, Otsuka H, Kuroda M, Honda Y, Sumiyoshi S, Inoue T, Kinoshita N, Nishida A, Yamashita K, Ito I, Komune S, Taguchi T, Iwamoto Y, Oda Y.
  • Journal Title: Virchows Arch. Volume: 470 Issue: 4 Pages: 373-380
  • DOI: 10.1007/s00428-017-2072-8
  • Peer Reviewed
• [Journal Article] Oncogenic roles of SMARCB1/INI1 and its deficient tumors. (2017)
  • Author(s): Kohashi K, Oda Y.
  • Journal Title: Cancer Sci. Volume: 印刷中 Issue: 4 Pages: 547-552
  • DOI: 10.1111/cas.13173
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] FOXO3a Expression Regulated by ERK Signaling is Inversely Correlated With Y-Box Binding Protein-1 Expression in Prostate Cancer. (2017)
  • Author(s): Imada K, Shiota M, Kuroiwa K, Sugimoto M, Abe T, Kohashi K, Yokomizo A, Eto M, Naito S, Oda Y.
  • Journal Title: Prostate. Volume: 77 Issue: 2 Pages: 145-153
  • DOI: 10.1002/pros.23254
  • Peer Reviewed
• [Journal Article] Phosphorylation of STAT3 in Undifferentiated Pleomorphic Sarcoma Is Correlated with a Favorable Prognosis. (2017)
  • Author(s): Bekki H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Otsuka H, Yamamoto H, Hakozaki M, Nabeshima K, Iwamoto Y, Oda Y.
  • Journal Title: Pathobiology. Volume: 印刷中
• [Journal Article] Cancer-testis antigen expression in synovial sarcoma: NY-ESO-1, PRAME, MAGEA4, and MAGEA1. (2016)
  • Author(s): Iura K, Maekawa A, Kohashi K, Ishii T, Bekki H, Otsuka H, Yamada Y, Yamamoto H, Harimaya K, Iwamoto Y, Oda Y.
  • Journal Title: Hum Pathol Volume: Mar;61 Pages: 130-139
  • DOI: 10.1016/j.humpath.2016.12.006
  • Peer Reviewed
• [Journal Article] Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma. (2016)
  • Author(s): Satoh S, Takatori A, Ogura A, Kohashi K, Souzaki R, Kinoshita Y, Taguchi T, Hossain MS, Ohira M, Nakamura Y, Nakagawara A.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 32682-32682
  • DOI: 10.1038/srep32682
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Significance of FOXM1 Expression and Antitumor Effect of FOXM1 Inhibition in Synovial Sarcomas (2016)
  • Author(s): Maekawa A, Kohashi K, Kuda M, Iura K, Ishii T, Endo M, Nakatsura T, Iwamoto Y, Oda Y
  • Journal Title: BMC Cancer Volume: 16 Issue: 1 Pages: 511-511
  • DOI: 10.1186/s12885-016-2542-4
  • Peer Reviewed / Open Access
• [Journal Article] Reclassification of rhabdoid tumor and pediatric undifferentiated/unclassified sarcoma with complete loss of SMARCB1/INI1 protein expression: three subtypes of rhabdoid tumor according to their histological features. (2016)
  • Author(s): Kohashi K, Tanaka Y, Kishimoto H, Yamamoto H, Yamada Y, Taguchi T, Iwamoto Y, Oda Y.
  • Journal Title: Mod Pathol. Volume: 29 Issue: 10 Pages: 1232-1242
  • DOI: 10.1038/modpathol.2016.106
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features. (2016)
  • Author(s): Sugimoto M, Kohashi K, Itsumi M, Shiota M, Abe T, Yamada Y, Kuroiwa K, Naito S, Oda Y.
  • Journal Title: Pathobiology. Volume: 83 Issue: 6 Pages: 277-286
  • DOI: 10.1159/000445752
  • Peer Reviewed
• [Journal Article] Prognostic Significance of Forkhead Box M1 (FOXM1) Expression and Antitumor Effect of FOXM1 Inhibition in Angiosarcoma. (2016)
  • Author(s): Ito T, Kohashi K, Yamada Y, Iwasaki T, Maekawa A, Kuda M, Hoshina D, Abe R, Furue M, Oda Y.
  • Journal Title: J Cancer Volume: Apr 27;7(7) Issue: 7 Pages: 823-30
  • DOI: 10.7150/jca.14461
  • Peer Reviewed / Open Access
• [Journal Article] Histological spectrum of angiofibroma of soft tissue: histological and genetic analysis of 13 cases. (2016)
  • Author(s): Yamada Y, Yamamoto H, Kohashi K, Ishii T, Iura K, Maekawa A, Bekki H, Otsuka H, Yamashita K, Tanaka H, Hiraki T, Mukai M, Shirakawa A, Shinnou Y, Jinno M, Yanai H, Taguchi K, Maehara Y, Iwamoto Y, Oda Y.
  • Journal Title: Histopathology. Volume: 69 Issue: 3 Pages: 459-469
  • DOI: 10.1111/his.12943
  • Peer Reviewed
• [Journal Article] Renal cell carcinoma with rhabdoid-like features lack intracytoplasmic inclusion bodies and show aggressive behavior. (2016)
  • Author(s): Sugimoto M, Kohashi K, Kuroiwa K, Abe T, Yamada Y, Shiota M, Imada K, Naito S, Oda Y.
  • Journal Title: Virchows Arch. Volume: 468 Issue: 3 Pages: 357-367
  • DOI: 10.1007/s00428-015-1885-6
  • Peer Reviewed
• [Journal Article] ALK, ROS1 and NTRK3 gene rearrangements in inflammatory myofibroblastic tumors. (2016)
  • Author(s): Yamamoto H, Yoshida A, Taguchi K, Kohashi K, Hatanaka Y, Yamashita A, Mori D, Oda Y
  • Journal Title: Histopathology Volume: 69(1) Issue: 1 Pages: 72-83
  • DOI: 10.1111/his.12910
  • Peer Reviewed
• [Journal Article] FOXM1 expression in rhabdomyosarcoma: a novel prognostic factor and therapeutic target. (2016)
  • Author(s): Kuda M, Kohashi K, Yamada Y, Maekawa A, Kinoshita Y, Nakatsura T, Iwamoto Y, Taguchi T, Oda Y.
  • Journal Title: Tumour Biol. Volume: 37 Issue: 4 Pages: 5213-23
  • DOI: 10.1007/s13277-015-4351-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Activation of the Akt-mTOR and MAPK pathways in dedifferentiated liposarcomas (2016)
  • Author(s): Ishii T, Kohashi K, Iura K, Maekawa A, Bekki H, Yamada Y, Yamamoto H, Nabeshima K, Kawashima H, Iwamoto Y, Oda Y
  • Journal Title: Tumor Biology Volume: 37(4) Issue: 4 Pages: 4767-4776
  • DOI: 10.1007/s13277-015-4232-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Expression of Forkhead box M1 in soft tissue leiomyosarcoma: Clinicopathologic and in vitro study using a newly established cell line. (2016)
  • Author(s): Maekawa A, Kohashi K, Setsu N, Kuda M, Iura K, Ishii T, Matsunobu T, Nakatsura T, Iwamoto Y, Oda Y.
  • Journal Title: Cancer Sci. Volume: 107 Issue: 1 Pages: 95-102
  • DOI: 10.1111/cas.12846
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum. (2015)
  • Author(s): Takahashi S, Kohashi K, Yamamoto H, Hirahashi M, Kumagai R, Takizawa N, Nakamura K, Maehara Y, Tanaka M, Takayanagi R, Oda Y.
  • Journal Title: Hum Pathol. Volume: 46 Issue: 9 Pages: 1257-66
  • DOI: 10.1016/j.humpath.2015.05.023
  • Peer Reviewed / Open Access
• [Journal Article] Mucinous phenotype and CD10 expression of primary adenocarcinoma of the small intestine. (2015)
  • Author(s): Kumagai R, Kohashi K, Takahashi S, Yamamoto H, Hirahashi M, Taguchi K, Nishiyama K, Oda Y.
  • Journal Title: World J Gastroenterol. Volume: 21 Issue: 9 Pages: 2700-10
  • DOI: 10.3748/wjg.v21.i9.2700
  • Peer Reviewed / Open Access
• [Journal Article] Amrubicin monotherapy for patients with extrapulmonary neuroendocrine carcinoma after platinum-based chemotherapy. (2015)
  • Author(s): Nio K, Arita S, Isobe T, Kusaba H, Kohashi K, Kajitani T, Tamura S, Hirano G, Mitsugi K, Makiyama A, Esaki T, Ariyama H, Oda Y, Akashi K, Baba E.
  • Journal Title: Cancer Chemother Pharmacol. Volume: 75 Issue: 4 Pages: 829-35
  • DOI: 10.1007/s00280-015-2706-y
  • Peer Reviewed
• [Journal Article] ERG and SALL4 expressions in SMARCB1/INI1-deficient tumors: a useful tool for distinguishing epithelioid sarcoma from malignant rhabdoid tumor. (2015)
  • Author(s): Kohashi K, Yamada Y, Hotokebuchi Y; Yamamoto H, Taguchi T, Iwamoto Y, Oda Y
  • Journal Title: Hum Pathology Volume: 46(2) Issue: 2 Pages: 225-230
  • DOI: 10.1016/j.humpath.2014.10.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Glypican 3 Expression in Pediatric Malignant Solid Tumors. (2015)
  • Author(s): Kinoshita Y, Tanaka S, Souzaki R, Miyoshi K, Kohashi K, Oda Y, Nakatsura T, Taguchi T.
  • Journal Title: Eur J Pediatr Surg. Volume: ２５ Issue: 01 Pages: 138-44
  • DOI: 10.1055/s-0034-1393961
  • Peer Reviewed / Open Access
• [Journal Article] Close correlation between CXCR4 and VEGF expression and frequent CXCR7 expression in rhabdomyosarcoma (2014)
  • Author(s): Miyoshi K, Kohashi K, Fushimi F, Yamamoto H, Taguchi T, Iwamoto Y, Oda Y
  • Journal Title: Hum Pathol Volume: 45(9) Issue: 9 Pages: 1900-1909
  • DOI: 10.1016/j.humpath.2014.05.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas (2014)
  • Author(s): Takahashi Y, Kohashi K, Yamada Y, Endo M, Setsu N, Ishii T, Yamamoto H, Iwamoto Y, Oda Y
  • Journal Title: Hum Pathol Volume: 45(5) Issue: 5 Pages: 984-993
  • DOI: 10.1016/j.humpath.2013.12.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Activation of the Akt-mTOR pathway and receptor tyrosine kinase in patients with solitary fibrous tumors. (2014)
  • Author(s): Yamada Y, Kohashi K, Fushimi F, Takahashi Y, Setsu N, Endo M, Yamamoto H, Tokunaga S, Iwamoto Y, Oda Y.
  • Journal Title: Cancer Volume: 未定 Issue: 6 Pages: 864-876
  • DOI: 10.1002/cncr.28506
  • Peer Reviewed / Open Access
• [Presentation] Clinicopathological and molecular features of dedifferentiated liposarcoma with ossification: A comparative study with dedifferentiated liposarcoma without ossification and extraskeletal osteosarcoma (2017)
  • Author(s): Yamashita K, Kohashi K, Yamada Y, Oda Y, Toyokuni S
  • Organizer: Annual Meeting of the United States and Canadian Academy of Pathology
  • Place of Presentation: San Antonio, USA
• [Presentation] SWI/SNF Chromatin Remodeling Complex Status in SMARCB1/INI1-Preserved Epithelioid Sarcoma Cases (2016)
  • Author(s): Kenichi Kohashi, Hidetaka Yamamoto, Yuichi Yamada, Yoshinao Oda.
  • Organizer: 2016 Annual Meeting of United States & Canadian Academy of Pathology
  • Place of Presentation: USA, Seattle
  • Year and Date: 2016-03-12
  • Int'l Joint Research
• [Presentation] Re-classification of rhabdoid tumor: three subtypes of rhabdoid tumor according to their histological features (2016)
  • Author(s): Kohashi K, Tanaka Y, Kishimoto H, Yamamoto H, Yamada Y, Kinoshita I, Taguchi T, Oda Y.
  • Organizer: 日本癌学会総会
  • Place of Presentation: 横浜
• [Presentation] 骨軟部腫瘍の新展開－新たな分類から治療まで (2015)
  • Author(s): 孝橋賢一
  • Organizer: 第74回関西小児病理研究会
  • Place of Presentation: 大阪市都島区
  • Year and Date: 2015-12-26
  • Invited
• [Presentation] ラブドイド腫瘍の病理診断：INI1-deficient tumorとrhabdoid feature up-to-date (2015)
  • Author(s): 孝橋賢一
  • Organizer: 小児腫瘍組織分類委員会症例検討会
  • Place of Presentation: 東京都世田谷区
  • Year and Date: 2015-08-28
  • Invited
• [Presentation] SMARCB1/INI1蛋白欠失腫瘍群におけるERG、SALL4発現の診断的意義の検討 (2015)
  • Author(s): 孝橋賢一、山田裕一、山元英崇、石井武彰、井浦国生、前川啓、戸次大史、大塚洋、岩本幸英、小田義直
  • Organizer: 第48回日本整形外科学会 骨・軟部腫瘍学術集会
  • Place of Presentation: 香川県高松市
  • Year and Date: 2015-07-10
• [Presentation] Expressions of Core Subunits of SWI/SNF Chromatin Remodeling Complex in SMARCB1/INI1-Deficient Tumors (2015)
  • Author(s): Kohashi K, Yamamoto H, Yamada Y, Oda Y.
  • Organizer: USCAP Annual Meeting
  • Place of Presentation: USA, Boston, MA
  • Year and Date: 2015-03-21 – 2015-03-27
• [Presentation] 癌精巣抗原PRAMEとNY−ESO−1の脂肪肉腫での発現と粘液／円形細胞型脂肪肉腫における臨床病理学的因子との関連. (2014)
  • Author(s): 井浦国生、孝橋賢一、石井武彰、前川啓、山田裕一、戸次大史、山元英崇、遠藤誠、岩本幸英、小田義直.
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 滑膜肉腫臨床検体におけるmelanoma inhibitory activity proteinの発現. (2014)
  • Author(s): 前川啓、孝橋賢一、井浦国生、石井武彰、高橋祐介、山田裕一、岩本幸英、小田義直.
  • Organizer: 日本整形外科学会 骨・軟部腫瘍学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-17 – 2014-07-18
• [Presentation] 隆起性皮膚線維肉腫におけるAkt/mTOR pathwayの解析. (2014)
  • Author(s): 佛淵由佳、山田裕一、孝橋賢一、山元英崇、古江増隆、岩本幸英、小田義直.
  • Organizer: 日本病理学会総会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26