Kalirin in atherothrombosis.

• Project/Area Number: 26460437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: University of Miyazaki
• Principal Investigator: Sato Yuichiro 宮崎大学, 医学部, 准教授 (90347055)
• Co-Investigator(Kenkyū-buntansha): 畠山 金太 奈良県立医科大学, 医学部, 准教授 (60325735) ; 山下 篤 宮崎大学, 医学部, 助教 (90372797)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 病理 / 動脈硬化 / 血栓症

Outline of Final Research Achievements

We studied the expression of kalirin in atherothrombosis. We could not detected in karilin in atherosclerotic or thrombosis lesions by immunohistochemically, in situ hybridization, or PCR examination. We found severe atherosclerosis in lower peripheral arteries in autopsies.

Research Products

• [Journal Article] Asymptomatic plaques of lower peripheral arteries and association with cardiovascular disease: An autopsy study. (2017)
  • Author(s): Eriko Nakamura, Yuichiro Sato, Takashi Iwakiri, Atsushi Yamashita, Sayaka Moriguchi-Goto, Kazunari Maekawa, Toshihiro Gi, Yujiro Asada
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Human Coronary Thrombus Formation Is Associated With Degree of Plaque Disruption and Expression of Tissue Factor and Hexokinase II. (2015)
  • Author(s): Okuyama N, Matsuda S, Yamashita A, Moriguchi-Goto S, Sameshima N, Iwakiri T, Matsuura Y, Sato Y, Asada Y.
  • Journal Title: Circ J Volume: 79 Pages: 2430-2438
  • NAID: 130005104878
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Histological severity of fetal inflammation is useful in predicting neonatal outcome. (2015)
  • Author(s): Yamada N, Sato Y, Moriguchi-Goto S, Yamashita A, Kodama Y, Sameshima H, Asada Y.
  • Journal Title: Placenta Volume: 36 Pages: 1490-1493
  • Peer Reviewed
• [Journal Article] Association between renal vasculature changes and generalized atherosclerosis: An autopsy survey. (2014)
  • Author(s): Iwakiri T., Sato Y.*, Matsuura Y., Hatakeyama K., Marutsuka K., Yamashita A., Fujimoto S., Kitamura K., Asada Y
  • Journal Title: J. Atheroscler. Thromb. Volume: 21 Pages: 99-107
  • NAID: 130004444703
  • Peer Reviewed
• [Presentation] Primitive neuroectodermal tumor (PNET)様成分と神経膠腫(glioma)成分がみられた脳腫瘍の2例. (2015)
  • Author(s): 佐藤勇一郎、盛口清香、山下篤、福島剛、浅田祐士郎.
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会場(愛知県、名古屋市）
  • Year and Date: 2015-04-30
• [Presentation] Chronic histiocytic intervillositis (CHI)の臨床病理組織学的検討. (2014)
  • Author(s): 佐藤勇一郎、盛口淸香、山下篤、浅田祐士郎、鮫島 浩
  • Organizer: 第22回日本胎盤学会学術集会
  • Place of Presentation: 京都府京都市京都大学
  • Year and Date: 2014-10-03 – 2014-10-04