Virus antigen specific CTL in HTLV-1 and EBV associated lymphoma
Project/Area Number |
26460446
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Kurume University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | ATLL / HTLV1 / TAX / FoxP3 / T reg / CTL / HLA A24 / HTLV-1 / HLA-A24 / Foxp3 |
Outline of Final Research Achievements |
HTLV-1 Tax has been reported to play an important role in ATLL and to be a target of HTLV-1-specific CTL. However, it is not clear how Tax-specific CTL behave in lymph nodes. We analyzed TAX-specific CTL. Furthermore, ATLL tumor cells are known to be positive for Foxp3 and to have regulatory T-cell (T-reg) like function. We also investigated the relationship between T-reg function and TAX-specific CTL. Immunohistochemical staining of tax protein showed positive lymphoma cells ranged 5% to 80%, and HLA-A24 showed positive cells ranged 1% to 95%. FoxP3 for T-reg were expressed in 0% to 90%. Some of cases showed Tax-specific CTL (HLA-A24-restricted) positive cells and there were inverse correlation between Tax-specific CTL and Foxp3. However, TAX and HLA A24 expression were not associated with CTL and FoxP3. The study showed the possibility that ATLL cells, which expressed TAX of CTL target, evade from CTL-mediated immune control by expression of FoxP3, as regulatory T cell function.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function2017
Author(s)
AYAKO ICHIKAWA, HIROAKI MIYOSHI, FUMIKO ARAKAWA, JUNICHI KIYASU, KENSAKU SATO, DAISUKE NIINO, YOSHIZO KIMURA, MAKI YOSHIDA, RIKO KAWANO, HIROKO MUTA, YASUO SUGITA, KOICHI OHSHIMA
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Journal Title
ONCOLOGY LETTERS
Volume: 13
Pages: 4611-4618
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] An Epstein-Barr virus susceptible immature T-cell line, WILL4, established from a patient with T-lymphoblastic lymphoma bearing CD21 and a clonal EBV genome.2017
Author(s)
Hosoi H, Imadome KI, Tamura S, Kuriyama K, Murata S, Yamashita Y, Mushino T, Oiwa T, Kobata H, Nishikawa A, Nakakuma H, Hanaoka N, Isobe Y, Ohshima K, Sonoki T.
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Journal Title
Leuk Res.
Volume: 55
Pages: 1-5
Related Report
Peer Reviewed
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[Journal Article] CCR4 frameshift mutation identifies a distinct group of adult T cell leukaemia/lymphoma with poor prognosis.2016
Author(s)
Yoshida N, Miyoshi H, Kato T, Sakata-Yanagimoto M, Niino D, Taniguchi H, Moriuchi Y, Miyahara M, Kurita D, Sasaki Y, Shimono J, Kawamoto K, Utsunomiya A, Imaizumi Y, Seto M, Ohshima K.
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Journal Title
J Pathol.
Volume: 238
Pages: 621-6
Related Report
Peer Reviewed
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[Journal Article] Analysis of the BRAFV600E mutation in 19 cases of Langerhans cell histiocytosis in Japan.2016
Author(s)
Sasaki Y, Guo Y, Arakawa F, Miyoshi H, Yoshida N, Koga Y, Nakashima K, Kurita D, Niino D, Seto M, Ohshima K.
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Journal Title
Hematol Oncol
Volume: -
Issue: 3
Pages: 329-334
DOI
Related Report
Peer Reviewed
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[Journal Article] A Clinicopathologic Study of Lennert Lymphoma and Possible Prognostic Factors: The Importance of Follicular Helper T-cell Markers and the Association With Angioimmunoblastic T-cell Lymphoma.2016
Author(s)
Kurita D, Miyoshi H, Yoshida N, Sasaki Y, Kato S, Niino D, Sugita Y, Hatta Y, Takei M, Makishima M, Ohshima K.
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Journal Title
Am J Surg Pathol.
Volume: 40
Pages: 1249-60
Related Report
Peer Reviewed
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[Journal Article] BRAFV600E and MAP2K1 mutations in Langerhans cell histiocytosis occur predominantly in children.2016
Author(s)
Zeng K, Ohshima K, Liu Y, Zhang W, Wang L, Fan L, Li M, Li X, Wang Z, Guo S, Yan Q, Guo Y.
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Journal Title
Hematol Oncol.
Volume: -
Issue: 4
Pages: 845-851
DOI
Related Report
Peer Reviewed
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[Journal Article] PD-L1 expression on neoplastic or stromal cells is respectively a poor or good prognostic factor for adult T-cell leukemia/lymphoma.2016
Author(s)
Miyoshi H, Kiyasu J, Kato T, Yoshida N, Shimono J, Yokoyama S, Taniguchi H, Sasaki Y, Kurita D, Kawamoto K, Kato K, Imaizumi Y, Seto M, Ohshima K.
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Journal Title
Blood.
Volume: 128
Pages: 1374-81
Related Report
Peer Reviewed
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[Journal Article] A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells).2016
Author(s)
Yoshida N, Kinugasa T, Miyoshi H, Sato K, Yuge K, Ohchi T, Fujino S, Shiraiwa S, Katagiri M, Akagi Y, Ohshima K.
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Journal Title
Ann Surg Oncol
Volume: 23
Pages: 919-927
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Anaplastic lymphoma kinase protein expression, genetic abnormalities, and phosphorylation in soft tissue tumors: Phosphorylation is associated with recurrent metastasis.2015
Author(s)
Ishibashi Y, Miyoshi H, Hiraoka K, Arakawa F, Haraguchi T, Nakashima S, Hashiguchi T, Shoda T, Hamada T, Okawa T, Higuchi F, Shiba N, Nagata K, Ohshima K.
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Journal Title
Oncol Rep
Volume: 33
Pages: 1667-1674
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative disorder in children and young adults has similar molecular signature to extranodal nasal natural killer/T-cell lymphoma but shows distinctive stem cell-like phenotype.2015
Author(s)
Ng SB, Ohshima K, Selvarajan V, Huang G, Choo SN, Miyoshi H, Shimizu N, Reghunathan R, Chua HC, Yeoh AE, Quah TC, Koh LP, Tan PL, Chng WJ.
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Journal Title
Leuk Lymphoma
Volume: 56
Pages: 2408-2415
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Prognostic impact of cytogenetic abnormalities in children and adolescents with mature B-cell non-Hodgkin lymphoma: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG).2015
Author(s)
Sekimizu M, Mori T, Kikuchi A, Mitsui T, Sunami S, Kobayashi R, Fujita N, Inada H, Takimoto T, Saito AM, Watanabe T, Fujimoto J, Nakazawa A, Ohshima K, Horibe K, Tsurusawa M; Lymphoma Committee of the Japanese Pediatric Leukemia/Lymphoma Study Group.
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Journal Title
Pediatr Blood Cancer
Volume: 62
Pages: 1294-1296
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma.2015
Author(s)
Kiyasu J, Miyoshi H, Hirata A, Arakawa F, Ichikawa A, Niino D, Sugita Y, Yufu Y, Choi I, Abe Y, Uike N, Nagafuji K, Okamura T, Akashi K, Takayanagi R, Shiratsuchi M, Ohshima K.
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Journal Title
Blood
Volume: 126
Pages: 2193-2201
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma.2014
Author(s)
Ito M, Teshima K, Ikeda S, Kitadate A, Watanabe A, Nara M, Yamashita J, Ohshima K, Sawada K, Tagawa H.
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Journal Title
Blood
Volume: 123
Pages: 1499-511
Related Report
Peer Reviewed
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[Journal Article] Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.2014
Author(s)
Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, Manachai N, Yamakawa N, Hamasaki M, Kitabayashi I, Arai Y, Kanai Y, Taki T, Abe T, Kiyonari H, Shimoda K, Ohshima K, Horii A, Shima H, Taniwaki M, Yamaguchi R, Morishita K.
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Journal Title
Nat Commun
Volume: 26
Pages: 3393-3393
Related Report
Peer Reviewed
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[Journal Article] Gene expression profiling of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly reveals alterations of characteristic oncogenetic pathways.2014
Author(s)
Kato H, Karube K, Yamamoto K, Takizawa J, Tsuzuki S, Yatabe Y, Kanda T, Katayama M, Ozawa Y, Ishitsuka K, Okamoto M, Kinoshita T, Ohshima K, Nakamura S, Morishima Y, Seto M.
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Journal Title
Cancer Sci
Volume: 105
Pages: 537-44
Related Report
Peer Reviewed